Seasonal variation of imipramine binding in the blood platelets of normal controls and depressed patients

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Imipramine binding (IB) was studied in the blood platelets from normal controls and depressed patients over a 4-year period (1981-1984) to determine if seasonal variation was present in Bmax or KD. Bimonthly variation in the Bmax of IB was found in normal controls studied longitudinally. No such variation was found when individual values from normal controls were examined on a monthly or seasonal basis. Bmax in depressed patients showed a significant seasonal, but not monthly, variation. KD of IB varied in normal controls using monthly or seasonal data, but not in the probably more reliable bimonthly data. These results suggest that IB studies comparing groups of subjects should match groups for season of the year or, for greater accuracy, month of the year.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalBiological psychiatry
Volume23
Issue number3
DOIs
StatePublished - Feb 1 1988

ASJC Scopus subject areas

  • Biological Psychiatry

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