Seasonal variation of serotonin uptake in normal controls and depressed patients

R. C. Arora, L. Kregel, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Serotonin (5-HT) uptake in blood platelets from depressed patients and normal controls were studied over a 2-year period to determine if seasonal variations were present. V(max), a measure of the number of 5-HT uptake sites in normal controls and depressed patients, was significantly higher in fall and winter than in spring and summer; V(max) in the depressed patients was lower than in normal controls throughout the year. Normal controls showed lower V(max) in April and June. A similar trend was present in the depressed patients but the lowest values were found in the month of December. The necessity of considering seasonal variations in this and other putative biological markers is emphasized.

Original languageEnglish (US)
Pages (from-to)795-804
Number of pages10
JournalBiological Psychiatry
Issue number6
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Biological Psychiatry


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