@article{5122ae19d54f454aa1616313d1581874,
title = "Sebaceous carcinoma: evidence-based clinical practice guidelines",
abstract = "Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. For diagnosis, we concluded that deep biopsy is often required; furthermore, differential diagnoses that mimic the condition can be excluded with special histological stains. For treatment, the recommended first-line therapy is surgical removal, followed by margin assessment of the peripheral and deep tissue edges; conjunctival mapping biopsies can facilitate surgical planning. Radiotherapy can be considered for cases with nerve or lymph node involvement, and as the primary treatment in patients who are ineligible for surgery. Post-treatment clinical examination should occur every 6 months for at least 3 years. No specific systemic therapies for advanced disease can be recommended, but targeted therapies and immunotherapies are being developed.",
author = "Owen, {Joshua L.} and Nour Kibbi and Brandon Worley and Kelm, {Ryan C.} and Wang, {Jordan V.} and Barker, {Christopher A.} and Ramona Behshad and Bichakjian, {Christopher K.} and Diana Bolotin and Bordeaux, {Jeremy S.} and Bradshaw, {Scott H.} and Cartee, {Todd V.} and Sunandana Chandra and Cho, {Nancy L.} and Choi, {Jennifer N.} and Council, {M. Laurin} and Hakan Demirci and Eisen, {Daniel B.} and Bita Esmaeli and Nicholas Golda and Huang, {Conway C.} and Ibrahim, {Sherrif F.} and Jiang, {S. Brian} and John Kim and Kuzel, {Timothy M.} and Lai, {Stephen Y.} and Naomi Lawrence and Lee, {Erica H.} and Leitenberger, {Justin J.} and Maher, {Ian A.} and Mann, {Margaret W.} and Kira Minkis and Mittal, {Bharat B.} and Nehal, {Kishwer S.} and Neuhaus, {Isaac M.} and Ozog, {David M.} and Brian Petersen and Veronica Rotemberg and Sandeep Samant and Samie, {Faramarz H.} and Sabah Servaes and Shields, {Carol L.} and Shin, {Thuzar M.} and Sobanko, {Joseph F.} and Somani, {Ally Khan} and Stebbins, {William G.} and Thomas, {J. Regan} and Thomas, {Valencia D.} and Tse, {David T.} and Waldman, {Abigail H.} and Wong, {Michael K.} and Xu, {Y. Gloria} and Yu, {Siegrid S.} and Zeitouni, {Nathalie C.} and Timothy Ramsay and Reynolds, {Kelly A.} and Emily Poon and Murad Alam",
note = "Funding Information: This study was partially supported by unrestricted research funding from the Section of Cutaneous Surgery in the Northwestern University Department of Dermatology (IL, USA). We thank Ellen Burke, a patient representative who contributed her perspective based on personal experiences with sebaceous carcinoma and helped shape the summary statement. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = dec,
doi = "10.1016/S1470-2045(19)30673-4",
language = "English (US)",
volume = "20",
pages = "e699--e714",
journal = "The Lancet Oncology",
issn = "1470-2045",
publisher = "Lancet Publishing Group",
number = "12",
}