Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y. Birnbaum, Alex Zvulunov, Dafna Hallel-Halevy, Emanuella Cagnano, Gal Finer, Rivka Ofir, Dan Geiger, Eldad Silberstein, Yael Feferman, Ohad S. Birk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

Original languageEnglish (US)
Pages (from-to)749-751
Number of pages3
JournalNature Genetics
Volume38
Issue number7
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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