Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y. Birnbaum, Alex Zvulunov, Dafna Hallel-Halevy, Emanuella Cagnano, Gal Finer, Rivka Ofir, Dan Geiger, Eldad Silberstein, Yael Feferman, Ohad S. Birk

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

Original languageEnglish (US)
Pages (from-to)749-751
Number of pages3
JournalNature Genetics
Volume38
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Keratinocytes
Parakeratosis
Lymphocytes
Seborrheic Dermatitis
Malassezia
Frameshift Mutation
Mutation
Skin Diseases
Proteins
Fibroblasts
Skin
Genes
Seborrhea-Like Dermatitis with Psoriasiform Elements
CYS2-HIS2 Zinc Fingers

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

Cite this

Birnbaum, Ramon Y. ; Zvulunov, Alex ; Hallel-Halevy, Dafna ; Cagnano, Emanuella ; Finer, Gal ; Ofir, Rivka ; Geiger, Dan ; Silberstein, Eldad ; Feferman, Yael ; Birk, Ohad S. / Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. In: Nature Genetics. 2006 ; Vol. 38, No. 7. pp. 749-751.
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Birnbaum, RY, Zvulunov, A, Hallel-Halevy, D, Cagnano, E, Finer, G, Ofir, R, Geiger, D, Silberstein, E, Feferman, Y & Birk, OS 2006, 'Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein' Nature Genetics, vol. 38, no. 7, pp. 749-751. https://doi.org/10.1038/ng1813

Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. / Birnbaum, Ramon Y.; Zvulunov, Alex; Hallel-Halevy, Dafna; Cagnano, Emanuella; Finer, Gal; Ofir, Rivka; Geiger, Dan; Silberstein, Eldad; Feferman, Yael; Birk, Ohad S.

In: Nature Genetics, Vol. 38, No. 7, 01.07.2006, p. 749-751.

Research output: Contribution to journalArticle

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AU - Hallel-Halevy, Dafna

AU - Cagnano, Emanuella

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AU - Feferman, Yael

AU - Birk, Ohad S.

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