Secondary CNS myeloma with remission after systemic CNS-penetrating agents

Luis G. Fernandez*, Daniel Eduardo Oyon, Vinai Gondi, Sean Grimm, Osaama H. Khan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: CNS myeloma is a rare manifestation of multiple myeloma and is often associated with a dismal prognosis; however, cases are increasing in frequency as overall survival improves for MM. There is currently no standardized treatment for CNS myeloma; however, different chemotherapy and radiotherapy regimens have been described. Methods: We had previously reported on the efficacy of proton-based craniospinal irradiation in a patient with CNS myeloma; here we present a patient with a history of extramedullary plasmacytoma, 10 years in remission status post standard systemic chemotherapy, with biopsy-proven CNS myeloma successfully treated with systemic chemotherapy as a first-line treatment. Results: The patient achieved clinical and radiographic remission on 2 separate occasions with systemic chemotherapy alone. Conclusions: This case demonstrates that systemically administered agents may have activity in CNS myeloma. Further investigations are necessary to establish the optimal combination of agents and treatment schedules.

Original languageEnglish (US)
Article numbervdac106
JournalNeuro-Oncology Advances
Issue number1
StatePublished - Jan 1 2022


  • CNS myeloma
  • craniospinal irradiation
  • leptomeningeal
  • multiple myeloma

ASJC Scopus subject areas

  • Clinical Neurology
  • Oncology
  • Surgery


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