Abstract
Patients with end-stage liver disease are prone to hemodynamic and immunologic renal injury, the latter at times manifesting as glomerulonephritis. Elevated serum immunoglobulin A (IgA) levels and mesangial IgG-IgA deposits are common in these patients, but are often clinically silent. We report a patient with autoimmune hepatitis and secondary IgA nephropathy (IgAN) who presented with nephrotic syndrome, acute renal failure (ARF), with 30% of the renal glomeruli having undergone crescentic change, and with IgA2 deposits in the glomerular mesangium. This article discusses secondary IgAN pathogenesis and its therapeutic management.
Original language | English (US) |
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Pages (from-to) | 125-129 |
Number of pages | 5 |
Journal | Journal of Nephrology |
Volume | 17 |
Issue number | 1 |
State | Published - Jan 1 2004 |
Keywords
- Acute renal failure
- Auto-immune hepatitis
- IgA nephropathy
- Mycophenolate mofetil
- Nephrotic syndrome
ASJC Scopus subject areas
- Nephrology