Secondary lgA nephropathy presenting as nephrotic syndrome with glomerular crescentic changes and acute renal failure in a patient with autoimmune hepatitis

Naveen Singri, Briana Gleason, Steve L. Flamm, Yashpal S. Kanwar, Cybele Ghossein*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Patients with end-stage liver disease are prone to hemodynamic and immunologic renal injury, the latter at times manifesting as glomerulonephritis. Elevated serum immunoglobulin A (IgA) levels and mesangial IgG-IgA deposits are common in these patients, but are often clinically silent. We report a patient with autoimmune hepatitis and secondary IgA nephropathy (IgAN) who presented with nephrotic syndrome, acute renal failure (ARF), with 30% of the renal glomeruli having undergone crescentic change, and with IgA2 deposits in the glomerular mesangium. This article discusses secondary IgAN pathogenesis and its therapeutic management.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalJournal of Nephrology
Volume17
Issue number1
StatePublished - Jan 1 2004

Keywords

  • Acute renal failure
  • Auto-immune hepatitis
  • IgA nephropathy
  • Mycophenolate mofetil
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Nephrology

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