Secretin facilitates GABA transmission in the cerebellum

Wing Ho Yung, Po Sing Leung, Samuel S M Ng, Jie Zhang, Savio C Y Chan, Billy K C Chow

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting reports on its effectiveness, urges an in-depth investigation of this issue. We show here that in the rat cerebellar cortex, mRNAs encoding secretin are localized in the Purkinje cells, whereas those of its receptor are found in both Purkinje cells and GABAergic interneurons. Immunoreactivity for secretin is localized in the soma and dendrites of Purkinje cells. In addition, secretin facilitates evoked, spontaneous, and miniature IPSCs recorded from Purkinje cells. We propose that secretin is released from the somatodendritic region of Purkinje cells and serves as a retrograde messenger modulating GABAergic afferent activity.

Original languageEnglish (US)
Pages (from-to)7063-7068
Number of pages6
JournalJournal of Neuroscience
Volume21
Issue number18
DOIs
StatePublished - Sep 15 2001

Keywords

  • Autism
  • Cerebellum
  • GABA
  • Inhibitory postsynaptic currents
  • Purkinje cells
  • Secretin

ASJC Scopus subject areas

  • Neuroscience(all)

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