Secretion granules of transplantable pancreatic acinar carcinoma of rat

J. K. Reddy, M. K. Reddy, L. J. Hansen, S. A. Qureshi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Secretion granules of the rat transplantable pancreatic acinar carcinoma and of normal rat pancreas were isolated by differential centrifugation. Analysis of the granule content by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis and isoelectric focusing procedures combined with specific enzyme assays indicated essential qualitative similarities between normal and neoplastic secretory proteins, suggesting retention of enzymic differentiation in this pancreatic acinar carcinoma. Accordingly, this epithelial tumour should serve as an important model for examination of regulatory mechanisms in cell differentiation and neoplasia.

Original languageEnglish (US)
Pages (from-to)921-924
Number of pages4
JournalBiochemical Journal
Volume188
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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