TY - JOUR
T1 - Secretory dynamics of bioactive and immunoreactive prolactin in polycystic ovary syndrome
AU - Anderson, R. E.
AU - Ben-Rafael, Z.
AU - Flickinger, G. L.
AU - Meloni, F.
AU - Barnes, R. B.
AU - Rosen, G. F.
AU - Lobo, R. A.
PY - 1988
Y1 - 1988
N2 - To further investigate prolactin (PRL) secretion in polycystic ovary syndrome (PCO), the authors evaluated immunoreactive (immuno) and bioactive (bio) PRL levels in the basal state and in response to provocative testing with intravenous dopamine (DA), metoclopramide (MCP), and gonadotropin-releasing hormone (GnRH), before and after disulfiram. Basal measurements of immuno-PRL, bio-PRL, and the ratio of bio/immuno-PRL were similar in PCO and controls. The immuno-PRL, decrement after DA was greater than that of bio-PRL in both groups (P < 0.05). After MCP, immuno-PRL increased more than bio-PRL in PCO (P < 0.01), and this immuno-PRL increment was greater than that of controls (P < 0.05). Bio-PRL and immuno-PRL increased after GnRH in PCO, but not controls, and these responses were inhibited by disulfiram. These data confirm PRL hypersecretion in some women with PCO, which is better expressed by immunoreactivity than bioactivity. Given the assay systems and patients studied, bioactivity of PRL appears to be normal in PCO.
AB - To further investigate prolactin (PRL) secretion in polycystic ovary syndrome (PCO), the authors evaluated immunoreactive (immuno) and bioactive (bio) PRL levels in the basal state and in response to provocative testing with intravenous dopamine (DA), metoclopramide (MCP), and gonadotropin-releasing hormone (GnRH), before and after disulfiram. Basal measurements of immuno-PRL, bio-PRL, and the ratio of bio/immuno-PRL were similar in PCO and controls. The immuno-PRL, decrement after DA was greater than that of bio-PRL in both groups (P < 0.05). After MCP, immuno-PRL increased more than bio-PRL in PCO (P < 0.01), and this immuno-PRL increment was greater than that of controls (P < 0.05). Bio-PRL and immuno-PRL increased after GnRH in PCO, but not controls, and these responses were inhibited by disulfiram. These data confirm PRL hypersecretion in some women with PCO, which is better expressed by immunoreactivity than bioactivity. Given the assay systems and patients studied, bioactivity of PRL appears to be normal in PCO.
UR - http://www.scopus.com/inward/record.url?scp=0023873729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023873729&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)59709-x
DO - 10.1016/s0015-0282(16)59709-x
M3 - Article
C2 - 3276562
AN - SCOPUS:0023873729
VL - 49
SP - 239
EP - 243
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -