Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)

Frans A. Kuypers*, Christina A. Rostad, Evan J. Anderson, Ann Chahroudi, Preeti Jaggi, Jens Wrammert, Grace Mantus, Rajit Basu, Frank Harris, Bradley Hanberry, Andres Camacho-Gonzalez, Shaminy Manoranjithan, Miriam Vos, Lou Ann Brown, Claudia R. Morris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Secretory phospholipase 2 (sPLA2) acts as a mediator between proximal and distal events of the inflammatory cascade. Its role in SARS-CoV-2 infection is unknown, but could contribute to COVID-19 inflammasome activation and cellular damage. We present the first report of plasma sPLA2 levels in adults and children with COVID-19 compared with controls. Currently asymptomatic adults with a history of recent COVID-19 infection (≥4 weeks before) identified by SARS-CoV-2 IgG antibodies had sPLA2 levels similar to those who were seronegative (9 ± 6 vs.17 ± 28 ng/mL, P = 0.26). In contrast, children hospitalized with severe COVID-19 had significantly elevated sPLA2 compared with those with mild or asymptomatic SARS-CoV-2 infection (269 ± 137 vs. 2 ± 3 ng/mL, P = 0.01). Among children hospitalized with multisystem inflammatory syndrome in children (MIS-C), all had severe disease requiring pediatric intensive care unit (PICU) admission. sPLA2 levels were significantly higher in those with acute illness <10 days versus convalescent disease ≥10 days (540 ± 510 vs. 2 ± 1, P = 0.04). Thus, sPLA2 levels correlated with COVID-19 severity and acute MIS-C in children, implicating a role in inflammasome activation and disease pathogenesis. sPLA2 may be a useful biomarker to stratify risk and guide patient management for children with acute COVID-19 and MIS-C. Therapeutic compounds targeting sPLA2 and inflammasome activation warrant consideration.

Original languageEnglish (US)
Pages (from-to)2543-2552
Number of pages10
JournalExperimental Biology and Medicine
Volume246
Issue number23
DOIs
StatePublished - Dec 2021

Keywords

  • COVID-19
  • SARS-CoVC-2
  • multisystem inflammatory syndrome in children
  • secretory phospholipase A2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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