Sedentary behavior is associated with colorectal adenoma recurrence in men

Christine L. Sardo Molmenti*, Elizabeth A. Hibler, Erin L. Ashbeck, Cynthia A. Thomson, David O. Garcia, Denise Roe, Robin B. Harris, Peter Lance, Martin Cisneroz, Maria Elena Martinez, Patricia A. Thompson, Elizabeth T. Jacobs

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.

Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.

Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.

Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.

Original languageEnglish (US)
Pages (from-to)1387-1395
Number of pages9
JournalCancer Causes and Control
Volume25
Issue number10
DOIs
StatePublished - Oct 11 2014

    Fingerprint

Keywords

  • Colon cancer
  • Colorectal adenoma
  • Physical activity
  • Sedentary behavior

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sardo Molmenti, C. L., Hibler, E. A., Ashbeck, E. L., Thomson, C. A., Garcia, D. O., Roe, D., Harris, R. B., Lance, P., Cisneroz, M., Martinez, M. E., Thompson, P. A., & Jacobs, E. T. (2014). Sedentary behavior is associated with colorectal adenoma recurrence in men. Cancer Causes and Control, 25(10), 1387-1395. https://doi.org/10.1007/s10552-014-0444-9