Sedentary behavior is associated with colorectal adenoma recurrence in men

Christine L. Sardo Molmenti*, Elizabeth A. Hibler, Erin L. Ashbeck, Cynthia A. Thomson, David O. Garcia, Denise Roe, Robin B. Harris, Peter Lance, Martin Cisneroz, Maria Elena Martinez, Patricia A. Thompson, Elizabeth T. Jacobs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.

Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.

Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.

Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.

Original languageEnglish (US)
Pages (from-to)1387-1395
Number of pages9
JournalCancer Causes and Control
Volume25
Issue number10
DOIs
StatePublished - Oct 11 2014

Keywords

  • Colon cancer
  • Colorectal adenoma
  • Physical activity
  • Sedentary behavior

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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