TY - JOUR
T1 - Sedentary behavior is associated with colorectal adenoma recurrence in men
AU - Sardo Molmenti, Christine L.
AU - Hibler, Elizabeth A.
AU - Ashbeck, Erin L.
AU - Thomson, Cynthia A.
AU - Garcia, David O.
AU - Roe, Denise
AU - Harris, Robin B.
AU - Lance, Peter
AU - Cisneroz, Martin
AU - Martinez, Maria Elena
AU - Thompson, Patricia A.
AU - Jacobs, Elizabeth T.
N1 - Publisher Copyright:
© 2014, Springer International Publishing Switzerland.
PY - 2014/10/11
Y1 - 2014/10/11
N2 - Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.
AB - Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.
KW - Colon cancer
KW - Colorectal adenoma
KW - Physical activity
KW - Sedentary behavior
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U2 - 10.1007/s10552-014-0444-9
DO - 10.1007/s10552-014-0444-9
M3 - Article
C2 - 25060482
AN - SCOPUS:84911006071
SN - 0957-5243
VL - 25
SP - 1387
EP - 1395
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -
