TY - JOUR
T1 - Sedentary behavior is associated with colorectal adenoma recurrence in men
AU - Sardo Molmenti, Christine L.
AU - Hibler, Elizabeth A.
AU - Ashbeck, Erin L.
AU - Thomson, Cynthia A.
AU - Garcia, David O.
AU - Roe, Denise
AU - Harris, Robin B.
AU - Lance, Peter
AU - Cisneroz, Martin
AU - Martinez, Maria Elena
AU - Thompson, Patricia A.
AU - Jacobs, Elizabeth T.
N1 - Funding Information:
Acknowledgments This work was supported by the National Institutes of Health/National Cancer Institute grants supporting the Wheat Bran Fiber and Ursodeoxcholic Acid Phase III Clinical Trials conducted at the Arizona Cancer Center (PA1CA41108) and the Arizona Cancer Center Core grant (P30CA023074).
Publisher Copyright:
© 2014, Springer International Publishing Switzerland.
PY - 2014/10/11
Y1 - 2014/10/11
N2 - Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.
AB - Purpose: The association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.Methods: Pooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.Results: No statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47 % higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95 % CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p trend = 0.03). No similar association was observed for women.Conclusions: This study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.
KW - Colon cancer
KW - Colorectal adenoma
KW - Physical activity
KW - Sedentary behavior
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U2 - 10.1007/s10552-014-0444-9
DO - 10.1007/s10552-014-0444-9
M3 - Article
C2 - 25060482
AN - SCOPUS:84911006071
SN - 0957-5243
VL - 25
SP - 1387
EP - 1395
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -
