Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

Robert T. Mankowski, Mylene Aubertin-Leheudre, Daniel P. Beavers, Anda Botoseneanu, Thomas W. Buford, Timothy Church, Nancy W. Glynn, Abby C. King, Christine Liu, Todd M. Manini, Anthony P. Marsh, Mary McDermott, Joe R. Nocera, Marco Pahor, Elsa S. Strotmeyer, Stephen D. Anton*, The LIFE Research Group

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7. ±5.3years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalExperimental Gerontology
Volume70
DOIs
StatePublished - Oct 1 2015

Keywords

  • Accelerometry
  • Aging
  • Disability
  • Glucose
  • Waist circumference

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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    Mankowski, R. T., Aubertin-Leheudre, M., Beavers, D. P., Botoseneanu, A., Buford, T. W., Church, T., Glynn, N. W., King, A. C., Liu, C., Manini, T. M., Marsh, A. P., McDermott, M., Nocera, J. R., Pahor, M., Strotmeyer, E. S., Anton, S. D., & The LIFE Research Group (2015). Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study. Experimental Gerontology, 70, 32-36. https://doi.org/10.1016/j.exger.2015.06.018