Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

Robert T. Mankowski; Mylene Aubertin-Leheudre; Daniel P. Beavers; Anda Botoseneanu; Thomas W. Buford; Timothy Church; Nancy W. Glynn; Abby C. King; Christine Liu; Todd M. Manini; Anthony P. Marsh; Mary McDermott; Joe R. Nocera; Marco Pahor; Elsa S. Strotmeyer; Stephen D. Anton; The LIFE Research Group

doi:10.1016/j.exger.2015.06.018

Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

Robert T. Mankowski, Mylene Aubertin-Leheudre, Daniel P. Beavers, Anda Botoseneanu, Thomas W. Buford, Timothy Church, Nancy W. Glynn, Abby C. King, Christine Liu, Todd M. Manini, Anthony P. Marsh, Mary McDermott, Joe R. Nocera, Marco Pahor, Elsa S. Strotmeyer, Stephen D. Anton^*, The LIFE Research Group

^*Corresponding author for this work

Medicine, General Medicine Division

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7. ±5.3years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.

Original language	English (US)
Pages (from-to)	32-36
Number of pages	5
Journal	Experimental Gerontology
Volume	70
DOIs	https://doi.org/10.1016/j.exger.2015.06.018
State	Published - Oct 1 2015

Funding

Support was provided by the University of Florida's Claude D. Pepper Older Americans Independence Center (NIH/NIA P30AG028740 ), and Clinical and Translational Science Institute (NIH/NCRR UL1TR000064 ). Stephen Anton was previously supported by the Thomas H. Maren Foundation. The LIFE Study is funded by a National Institutes of Health/National Institute on Aging Cooperative Agreement # U01AG22376 and a supplement from the National Heart, Lung and Blood Institute ( 3U01AG022376 ). It is sponsored in part by the Intramural Research Program, National Institute on Aging, National Institutes of Health . Complete acknowledgments and funding information are shown in the Appendix and are available at: https://www.thelifestudy.org/docs/LIFE-AcknowledgementList11_2014-02-17_Full%20List_clean.pdf .

Keywords

Accelerometry
Aging
Disability
Glucose
Waist circumference

ASJC Scopus subject areas

Genetics
Endocrinology
Aging
Molecular Biology
Biochemistry
Cell Biology

Access to Document

10.1016/j.exger.2015.06.018

Cite this

Mankowski, R. T., Aubertin-Leheudre, M., Beavers, D. P., Botoseneanu, A., Buford, T. W., Church, T., Glynn, N. W., King, A. C., Liu, C., Manini, T. M., Marsh, A. P., McDermott, M., Nocera, J. R., Pahor, M., Strotmeyer, E. S., Anton, S. D., & The LIFE Research Group (2015). Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study. Experimental Gerontology, 70, 32-36. https://doi.org/10.1016/j.exger.2015.06.018

@article{246a66323d8e440ba334ddbed9afc1d3,

title = "Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study",

abstract = "Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7. ±5.3years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.",

keywords = "Accelerometry, Aging, Disability, Glucose, Waist circumference",

author = "Mankowski, {Robert T.} and Mylene Aubertin-Leheudre and Beavers, {Daniel P.} and Anda Botoseneanu and Buford, {Thomas W.} and Timothy Church and Glynn, {Nancy W.} and King, {Abby C.} and Christine Liu and Manini, {Todd M.} and Marsh, {Anthony P.} and Mary McDermott and Nocera, {Joe R.} and Marco Pahor and Strotmeyer, {Elsa S.} and Anton, {Stephen D.} and {The LIFE Research Group}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc..",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.exger.2015.06.018",

language = "English (US)",

volume = "70",

pages = "32--36",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

}

Mankowski, RT, Aubertin-Leheudre, M, Beavers, DP, Botoseneanu, A, Buford, TW, Church, T, Glynn, NW, King, AC, Liu, C, Manini, TM, Marsh, AP, McDermott, M, Nocera, JR, Pahor, M, Strotmeyer, ES, Anton, SD & The LIFE Research Group 2015, 'Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study', Experimental Gerontology, vol. 70, pp. 32-36. https://doi.org/10.1016/j.exger.2015.06.018

TY - JOUR

T1 - Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

AU - Mankowski, Robert T.

AU - Aubertin-Leheudre, Mylene

AU - Beavers, Daniel P.

AU - Botoseneanu, Anda

AU - Buford, Thomas W.

AU - Church, Timothy

AU - Glynn, Nancy W.

AU - King, Abby C.

AU - Liu, Christine

AU - Manini, Todd M.

AU - Marsh, Anthony P.

AU - McDermott, Mary

AU - Nocera, Joe R.

AU - Pahor, Marco

AU - Strotmeyer, Elsa S.

AU - Anton, Stephen D.

AU - The LIFE Research Group

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7. ±5.3years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.

AB - Background: Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. Methods: The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7. ±5.3years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI. Results: Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile. Conclusions: Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.

KW - Accelerometry

KW - Aging

KW - Disability

KW - Glucose

KW - Waist circumference

UR - http://www.scopus.com/inward/record.url?scp=84938909279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938909279&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2015.06.018

DO - 10.1016/j.exger.2015.06.018

M3 - Article

C2 - 26130060

AN - SCOPUS:84938909279

SN - 0531-5565

VL - 70

SP - 32

EP - 36

JO - Experimental Gerontology

JF - Experimental Gerontology

ER -

Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE Study

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this