Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease

Robert Vassar*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

Apolipoprotein E4 (apoE4) is the strongest genetic risk factor for Alzheimer's disease. Despite nearly 25 years of research, the mechanism by which apoE4 confers increased risk for Alzheimer's disease remains enigmatic. In this issue of Neuron, Liu et al. (2017) and Huynh et al. (2017) shed new light on this important question. Apolipoprotein E4 (apoE4) is the strongest genetic risk factor for Alzheimer's disease. Despite nearly 25 years of research, the mechanism by which apoE4 confers increased risk for Alzheimer's disease remains enigmatic. In this issue of Neuron, Liu et al. (2017) and Huynh et al. (2017) shed new light on this important question.

Original languageEnglish (US)
Pages (from-to)953-955
Number of pages3
JournalNeuron
Volume96
Issue number5
DOIs
StatePublished - Dec 6 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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