Segmental myocardial velocities in dilated cardiomyopathy with and without left bundle branch block

Daniela Foell*, Bernd A. Jung, Elfriede Germann, Felix Staehle, Christoph Bode, Juergen Hennig, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: To quantify three-directional left ventricular (LV) myocardial velocities and intraventricular synchrony in dilated cardiomyopathy (DCM) with and without left bundle branch block (LBBB) using MR tissue phase mapping (TPM). Materials and Methods: Regional velocities were assessed by TPM (spatial/temporal resolution = 1.3 × 1.3 mm2 × 8 mm/14 ms) in DCM patients with (n = 12) and without LBBB (n = 7) compared with age-matched volunteers (n = 20). For the evaluation the AHA 16-segment and an extended LV visualization model was used. Results: Radial velocities in DCM patients were reduced in 75% (systole) and in 94% (diastole) (P = 0.0001 - P = 0.0360), long-axis velocities in 31% (systole) and in 75% (diastole) of the 16 segments compared with controls (P = 0.0001 - P = 0.0310). LBBB resulted in inferolaterally delayed diastolic long-axis velocities (P = 0.0012 - P = 0.0464) and shortened TTP for septal systolic radial velocities (P = 0.0002). Intra-ventricular radial systolic TTP differed up to 150 ms between segments in patients with LBBB (89 ms without LBBB, 34 ms in volunteers) reflecting an increased dyssynchrony. LV twist was altered in all patients with reduced and delayed systolic and diastolic peak velocities. Conclusion: TPM identified previously not described alterations of the spatial distribution and timing of all myocardial velocities in patients with DCM and LBBB. This may help to optimize therapy management in future. J. Magn. Reson. Imaging 2013;37:119-126. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume37
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • dilated cardiomyopathy
  • left bundle branch block
  • phase contrast imaging
  • regional myocardial motion
  • tissue phase mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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