Segregation of a supernumerary del(15) marker chromosome in sperm

Philip D. Cotter*, E. Ko, S. K. Larabell, A. W. Rademaker, R. H. Martin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Supernumerary marker chromosomes (SMC) can be associated with both normal and abnormal phenotypes. In addition, SMC are found at higher frequency in males with infertility. We identified a SMC, characterized as a del(15)(q11.2) chromosome, in a phenotypically normal male. Using fluorescence in situ hybridization (FISH), we examined the segregation of the del(15) chromosome in sperm from this patient. Only 6.23% of sperm nuclei showed disomy using a chromosome 15 α-satellite FISH probe, instead of the expected 50%. In addition, FISH analysis showed no increase for non-disjunction of chromosome 18, excluding an interchromosomal effect for this chromosome. The significant decrease in sperm bearing the del(15) may be due to tissue-specific mosaicism or a result of some form of selection against the del(15) during spermatogenesis. This finding provides a basis for the observation that SMC(15) are less likely to be inherited from a paternal carrier.

Original languageEnglish (US)
Pages (from-to)488-492
Number of pages5
JournalClinical Genetics
Issue number6
StatePublished - 2000


  • Chromosome 15
  • Fluorescence in situ hybridization
  • Spermatocytes
  • Supernumerary marker chromosome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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