Seizures as a potential complication of treatment with simeprevir and sofosbuvir

Gaurav Syal, Seth D. Heldenbrand, Andres Duarte-Rojo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Newer direct-acting antiviral agents have revolutionized the medical management of chronic hepatitis C. In addition to being extremely efficacious, they report very mild adverse drug reactions from experience in clinical trials. However, because they are relatively new on the horizon, postmarketing surveillance studies refining the safety profile are not yet available. We present a case of seizures as a potential side effect of antiviral therapy with sofosbuvir and simeprevir.

Original languageEnglish (US)
Pages (from-to)e570-e571
JournalAmerican journal of therapeutics
Volume23
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • adverse drug reaction
  • direct-acting antivirals
  • hepatitis C
  • pharmacokinetics
  • side effect

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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