Select macrophage noncoding rnas of interest in cardiovascular disease

Zenaida Enchill, Connor Lantz, Edward B. Thorp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are correlated with macrophage activation and macrophage polarization of the transcriptome and secretome. In this setting, noncoding RNAs (ncRNAs) may be as abundant as protein-coding genes and are increasingly recognized as significant modulators of macrophage gene expression and cytokine secretion, although the functions of most ncRNAs—and in particular, long non-coding RNAs—remain unknown. Herein, we discuss a subset of specific ncRNAs of interest in macrophages in atherosclerosis and during myocardial inflammation.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Lipid and Atherosclerosis
Issue number1
StatePublished - 2020


  • Cardiovascular diseases
  • LncRNA
  • Macrophages

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine


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