TY - JOUR
T1 - Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation
AU - Ley, Klaus
AU - Kansas, Geoffrey S.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by many effector and memory T cells after initial antigen encounter. This review discusses the role of E-, P- and L-selectin and their glycoprotein ligands in this process. During activation, some T cells differentiate to bind E-selectin through induced expression of fucosyltransferase-VII and to bind P- and L-selectin through additional expression of core 2 glucosaminyltransferase-I. This inducible expression of selectin ligands, together with the regulation of L-selectin expression, has a role in the recruitment of activated T cells to extralymphoid tissues and sites of inflammation.
AB - The ability to home to extralymphoid tissues, such as the skin, lungs and gut, is acquired by many effector and memory T cells after initial antigen encounter. This review discusses the role of E-, P- and L-selectin and their glycoprotein ligands in this process. During activation, some T cells differentiate to bind E-selectin through induced expression of fucosyltransferase-VII and to bind P- and L-selectin through additional expression of core 2 glucosaminyltransferase-I. This inducible expression of selectin ligands, together with the regulation of L-selectin expression, has a role in the recruitment of activated T cells to extralymphoid tissues and sites of inflammation.
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M3 - Review article
C2 - 15122198
AN - SCOPUS:2442519018
SN - 1474-1733
VL - 4
SP - 325
EP - 335
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 5
ER -