Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks

Sungshin Kim, Aneesha S. Nilakantan, Molly S. Hermiller, Robert T. Palumbo, Stephen Anthony VanHaerents, Joel L Voss*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Posterior-medial and anterior-temporal cortical networks interact with the hippocampus and are thought to distinctly support episodic memory. We causally tested this putative distinction by determining whether targeted noninvasive stimulation could selectively affect neural signals of memory formation within the posterior-medial network. Stimulation enhanced the posterior-medial network’s evoked response to stimuli during memory formation, and this activity increase was coherent throughout the network. In contrast, there was no increase in anterior-temporal network activity due to stimulation. In addition, control stimulation of an out-of-network prefrontal cortex location in a separate group of subjects did not influence memory-related activity in either network. The posterior-medial network is therefore a functional unit for memory processing that is distinct from the anterior-temporal network. These findings suggest that targeted stimulation can lead to network-specific increases in excitability during memory formation and hold promise for efforts to fine-tune network involvement in episodic memory via brain stimulation.

Original languageEnglish (US)
Article numbereaar2768
JournalScience Advances
Volume4
Issue number8
DOIs
StatePublished - Aug 22 2018

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Episodic Memory
Prefrontal Cortex
Hippocampus
Brain

ASJC Scopus subject areas

  • General

Cite this

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title = "Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks",
abstract = "Posterior-medial and anterior-temporal cortical networks interact with the hippocampus and are thought to distinctly support episodic memory. We causally tested this putative distinction by determining whether targeted noninvasive stimulation could selectively affect neural signals of memory formation within the posterior-medial network. Stimulation enhanced the posterior-medial network’s evoked response to stimuli during memory formation, and this activity increase was coherent throughout the network. In contrast, there was no increase in anterior-temporal network activity due to stimulation. In addition, control stimulation of an out-of-network prefrontal cortex location in a separate group of subjects did not influence memory-related activity in either network. The posterior-medial network is therefore a functional unit for memory processing that is distinct from the anterior-temporal network. These findings suggest that targeted stimulation can lead to network-specific increases in excitability during memory formation and hold promise for efforts to fine-tune network involvement in episodic memory via brain stimulation.",
author = "Sungshin Kim and Nilakantan, {Aneesha S.} and Hermiller, {Molly S.} and Palumbo, {Robert T.} and VanHaerents, {Stephen Anthony} and Voss, {Joel L}",
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Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks. / Kim, Sungshin; Nilakantan, Aneesha S.; Hermiller, Molly S.; Palumbo, Robert T.; VanHaerents, Stephen Anthony; Voss, Joel L.

In: Science Advances, Vol. 4, No. 8, eaar2768, 22.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks

AU - Kim, Sungshin

AU - Nilakantan, Aneesha S.

AU - Hermiller, Molly S.

AU - Palumbo, Robert T.

AU - VanHaerents, Stephen Anthony

AU - Voss, Joel L

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N2 - Posterior-medial and anterior-temporal cortical networks interact with the hippocampus and are thought to distinctly support episodic memory. We causally tested this putative distinction by determining whether targeted noninvasive stimulation could selectively affect neural signals of memory formation within the posterior-medial network. Stimulation enhanced the posterior-medial network’s evoked response to stimuli during memory formation, and this activity increase was coherent throughout the network. In contrast, there was no increase in anterior-temporal network activity due to stimulation. In addition, control stimulation of an out-of-network prefrontal cortex location in a separate group of subjects did not influence memory-related activity in either network. The posterior-medial network is therefore a functional unit for memory processing that is distinct from the anterior-temporal network. These findings suggest that targeted stimulation can lead to network-specific increases in excitability during memory formation and hold promise for efforts to fine-tune network involvement in episodic memory via brain stimulation.

AB - Posterior-medial and anterior-temporal cortical networks interact with the hippocampus and are thought to distinctly support episodic memory. We causally tested this putative distinction by determining whether targeted noninvasive stimulation could selectively affect neural signals of memory formation within the posterior-medial network. Stimulation enhanced the posterior-medial network’s evoked response to stimuli during memory formation, and this activity increase was coherent throughout the network. In contrast, there was no increase in anterior-temporal network activity due to stimulation. In addition, control stimulation of an out-of-network prefrontal cortex location in a separate group of subjects did not influence memory-related activity in either network. The posterior-medial network is therefore a functional unit for memory processing that is distinct from the anterior-temporal network. These findings suggest that targeted stimulation can lead to network-specific increases in excitability during memory formation and hold promise for efforts to fine-tune network involvement in episodic memory via brain stimulation.

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