TY - JOUR
T1 - Selective depression of interferon-γ and granulysin production with increase of proliferative response by Vγ9/Vδ2 T cells in children with tuberculosis
AU - Dieli, Francesco
AU - Sireci, Guido
AU - Caccamo, Nadia
AU - Di Sano, Caterina
AU - Titone, Lucina
AU - Romano, Amelia
AU - Di Carlo, Paola
AU - Barera, Annalisa
AU - Accardo-Palumbo, Antonia
AU - Krensky, Alan M.
AU - Salerno, Alfredo
N1 - Funding Information:
Financial support: Italian National Research Council (to F.D.); Ministry for Education and Scientific and Technologic Research (to A.S. and F.D.); European Commission (contract QLK2-1999-00367 to F.D.).
PY - 2002/12/15
Y1 - 2002/12/15
N2 - Vγ9/Vδ2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vγ9/Vδ2 T cells from tuberculin purified protein derivative (PPD)-positive children, either healthy or affected by different clinical forms of tuberculosis, strongly proliferate to different phosphoantigens in vitro, whereas Vγ9/Vδ2 T cells from PPD-negative healthy subjects proliferate very poorly. We report here that Vγ9/Vδ2 T cells from tuberculous children have an increased proliferative activity, but decreased interferon (IFN)-γ production and granulysin expression. After successful chemotherapy, the Vγ9/Vδ2 T cell proliferative response strongly decreased, whereas IFN-γ and granulysin production consistently increased. Disease-associated changes in Vγ9/Vδ2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection.
AB - Vγ9/Vδ2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vγ9/Vδ2 T cells from tuberculin purified protein derivative (PPD)-positive children, either healthy or affected by different clinical forms of tuberculosis, strongly proliferate to different phosphoantigens in vitro, whereas Vγ9/Vδ2 T cells from PPD-negative healthy subjects proliferate very poorly. We report here that Vγ9/Vδ2 T cells from tuberculous children have an increased proliferative activity, but decreased interferon (IFN)-γ production and granulysin expression. After successful chemotherapy, the Vγ9/Vδ2 T cell proliferative response strongly decreased, whereas IFN-γ and granulysin production consistently increased. Disease-associated changes in Vγ9/Vδ2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection.
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U2 - 10.1086/345766
DO - 10.1086/345766
M3 - Article
C2 - 12447771
AN - SCOPUS:0037115026
SN - 0022-1899
VL - 186
SP - 1835
EP - 1839
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
