Selective depression of interferon-γ and granulysin production with increase of proliferative response by Vγ9/Vδ2 T cells in children with tuberculosis

Francesco Dieli*, Guido Sireci, Nadia Caccamo, Caterina Di Sano, Lucina Titone, Amelia Romano, Paola Di Carlo, Annalisa Barera, Antonia Accardo-Palumbo, Alan M. Krensky, Alfredo Salerno

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Vγ9/Vδ2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vγ9/Vδ2 T cells from tuberculin purified protein derivative (PPD)-positive children, either healthy or affected by different clinical forms of tuberculosis, strongly proliferate to different phosphoantigens in vitro, whereas Vγ9/Vδ2 T cells from PPD-negative healthy subjects proliferate very poorly. We report here that Vγ9/Vδ2 T cells from tuberculous children have an increased proliferative activity, but decreased interferon (IFN)-γ production and granulysin expression. After successful chemotherapy, the Vγ9/Vδ2 T cell proliferative response strongly decreased, whereas IFN-γ and granulysin production consistently increased. Disease-associated changes in Vγ9/Vδ2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection.

Original languageEnglish (US)
Pages (from-to)1835-1839
Number of pages5
JournalJournal of Infectious Diseases
Volume186
Issue number12
DOIs
StatePublished - Dec 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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