Selective Disruption of One Cartesian Axis of Cortical Maps and Receptive Fields by Deficiency in Ephrin-As and Structured Activity

Jianhua Cang; Cristopher M. Niell; Xiaorong Liu; Cory Pfeiffenberger; David A. Feldheim; Michael P. Stryker

doi:10.1016/j.neuron.2007.12.025

Selective Disruption of One Cartesian Axis of Cortical Maps and Receptive Fields by Deficiency in Ephrin-As and Structured Activity

Jianhua Cang, Cristopher M. Niell, Xiaorong Liu, Cory Pfeiffenberger, David A. Feldheim^*, Michael P. Stryker

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

The topographic representation of visual space is preserved from retina to thalamus to cortex. We have previously shown that precise mapping of thalamocortical projections requires both molecular cues and structured retinal activity. To probe the interaction between these two mechanisms, we studied mice deficient in both ephrin-As and retinal waves. Functional and anatomical cortical maps in these mice were nearly abolished along the nasotemporal (azimuth) axis of the visual space. Both the structure of single-cell receptive fields and large-scale topography were severely distorted. These results demonstrate that ephrin-As and structured neuronal activity are two distinct pathways that mediate map formation in the visual cortex and together account almost completely for the formation of the azimuth map. Despite the dramatic disruption of azimuthal topography, the dorsoventral (elevation) map was relatively normal, indicating that the two axes of the cortical map are organized by separate mechanisms.

Original language	English (US)
Pages (from-to)	511-523
Number of pages	13
Journal	Neuron
Volume	57
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2007.12.025
State	Published - Feb 28 2008

Funding

The work was supported by US National Institutes of Health (NIH) grants EY014689 (D.A.F.) and EY02874 (M.P.S.). J.C. was an Aventis Pharmaceuticals Fellow of the Life Sciences Research Foundation, and C.M.N. is a Helen Hay Whitney Foundation Fellow. We thank members of the Feldheim and Stryker labs for thoughtful discussion, Dr. Tom Bozza for the use of a confocal microscope, and Dr. David Ferster for the use of a Vibratome.

Keywords

DEVBIO
MOLNEURO
SYSBIO

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2007.12.025

Cite this

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title = "Selective Disruption of One Cartesian Axis of Cortical Maps and Receptive Fields by Deficiency in Ephrin-As and Structured Activity",

abstract = "The topographic representation of visual space is preserved from retina to thalamus to cortex. We have previously shown that precise mapping of thalamocortical projections requires both molecular cues and structured retinal activity. To probe the interaction between these two mechanisms, we studied mice deficient in both ephrin-As and retinal waves. Functional and anatomical cortical maps in these mice were nearly abolished along the nasotemporal (azimuth) axis of the visual space. Both the structure of single-cell receptive fields and large-scale topography were severely distorted. These results demonstrate that ephrin-As and structured neuronal activity are two distinct pathways that mediate map formation in the visual cortex and together account almost completely for the formation of the azimuth map. Despite the dramatic disruption of azimuthal topography, the dorsoventral (elevation) map was relatively normal, indicating that the two axes of the cortical map are organized by separate mechanisms.",

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note = "Funding Information: The work was supported by US National Institutes of Health (NIH) grants EY014689 (D.A.F.) and EY02874 (M.P.S.). J.C. was an Aventis Pharmaceuticals Fellow of the Life Sciences Research Foundation, and C.M.N. is a Helen Hay Whitney Foundation Fellow. We thank members of the Feldheim and Stryker labs for thoughtful discussion, Dr. Tom Bozza for the use of a confocal microscope, and Dr. David Ferster for the use of a Vibratome. ",

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AU - Stryker, Michael P.

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