Selective impairment of declarative memory following stimulation of dentate gyrus granule cells: a naloxone-sensitive effect

Timothy J. Collier*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memory ('knowing that' a particular maze location contains food) while leaving procedural memory intact ('knowing how' to search for food in the maze). This specific memory impairment was prevented by pretreatment with the opiate antagonist naloxone. Naloxone also improved memory performance when given to non-stimulated subjects.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalBrain research
Volume310
Issue number2
DOIs
StatePublished - Sep 24 1984

Keywords

  • brain stimulation
  • granule cells
  • memory
  • naloxone
  • opioids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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