Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Charles Z. Ding, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.

Original languageEnglish (US)
Pages (from-to)2077-2078
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number10
DOIs
StatePublished - Oct 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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