TY - JOUR
T1 - Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether
AU - Ding, Charles Z.
AU - Silverman, Richard B.
N1 - Funding Information:
of MAO B as measuredb y the efficiency, (kinact/KI)B/(kinact/KI)Ais, 1700. Acknowledgment. We are grateful to the National Instituteso f Health (Grant GM32634) for financial support of this researcha nd to Dr. Rona R. Ramsay (V. A. Medical Center, San Francisco) for donatingt he MAO A.
PY - 1993/10
Y1 - 1993/10
N2 - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.
AB - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.
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U2 - 10.1016/S0960-894X(01)81019-2
DO - 10.1016/S0960-894X(01)81019-2
M3 - Article
AN - SCOPUS:0027519804
VL - 3
SP - 2077
EP - 2078
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 10
ER -