Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Charles Z. Ding; Richard B. Silverman

doi:10.1016/S0960-894X(01)81019-2

Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Charles Z. Ding, Richard B. Silverman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (k_inact/K_I)_B/(k_inact/K_I)_A, is 1700.

Original language	English (US)
Pages (from-to)	2077-2078
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(01)81019-2
State	Published - Oct 1993

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(01)81019-2

Fingerprint Dive into the research topics of 'Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether'. Together they form a unique fingerprint.

Cite this

@article{6c7705a1e96d40a08a05b642c2826b65,

title = "Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether",

abstract = "Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.",

author = "Ding, {Charles Z.} and Silverman, {Richard B.}",

year = "1993",

month = oct,

doi = "10.1016/S0960-894X(01)81019-2",

language = "English (US)",

volume = "3",

pages = "2077--2078",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "10",

}

TY - JOUR

T1 - Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

AU - Ding, Charles Z.

AU - Silverman, Richard B.

PY - 1993/10

Y1 - 1993/10

N2 - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.

AB - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.

UR - http://www.scopus.com/inward/record.url?scp=0027519804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027519804&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)81019-2

DO - 10.1016/S0960-894X(01)81019-2

M3 - Article

AN - SCOPUS:0027519804

VL - 3

SP - 2077

EP - 2078

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 10

ER -