Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Charles Z. Ding; Richard B. Silverman

doi:10.1016/S0960-894X(01)81019-2

Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Charles Z. Ding, Richard B. Silverman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (k_inact/K_I)_B/(k_inact/K_I)_A, is 1700.

Original language	English (US)
Pages (from-to)	2077-2078
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(01)81019-2
State	Published - Oct 1993

Funding

of MAO B as measuredb y the efficiency, (kinact/KI)B/(kinact/KI)Ais, 1700. Acknowledgment. We are grateful to the National Instituteso f Health (Grant GM32634) for financial support of this researcha nd to Dr. Rona R. Ramsay (V. A. Medical Center, San Francisco) for donatingt he MAO A.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether",

abstract = "Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.",

author = "Ding, {Charles Z.} and Silverman, {Richard B.}",

note = "Funding Information: of MAO B as measuredb y the efficiency, (kinact/KI)B/(kinact/KI)Ais, 1700. Acknowledgment. We are grateful to the National Instituteso f Health (Grant GM32634) for financial support of this researcha nd to Dr. Rona R. Ramsay (V. A. Medical Center, San Francisco) for donatingt he MAO A.",

year = "1993",

month = oct,

doi = "10.1016/S0960-894X(01)81019-2",

language = "English (US)",

volume = "3",

pages = "2077--2078",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "10",

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TY - JOUR

T1 - Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

AU - Ding, Charles Z.

AU - Silverman, Richard B.

N1 - Funding Information: of MAO B as measuredb y the efficiency, (kinact/KI)B/(kinact/KI)Ais, 1700. Acknowledgment. We are grateful to the National Instituteso f Health (Grant GM32634) for financial support of this researcha nd to Dr. Rona R. Ramsay (V. A. Medical Center, San Francisco) for donatingt he MAO A.

PY - 1993/10

Y1 - 1993/10

N2 - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.

AB - Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3-chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time-dependent reversible inactivator of both monoamine oxidase A and B. The selectivity for inactivation of monoamine oxidase B, as measured by (kinact/KI)B/(kinact/KI )A, is 1700.

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SN - 0960-894X

VL - 3

SP - 2077

EP - 2078

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Selective inactivation of monoamine oxidase B by aminoethyl 3-chlorobenzyl ether

Abstract

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