Abstract
A single 20 mg/kg dose of 3,4-methylenedioxymethamphetamine (MDMA) administered to rats markedly decreased serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in hippocampus, frontal cortex and striatum seven days following injection. MDMA also significantly decreased type II glucocorticoid receptor levels in the striatum, but not in hippocampus or frontal cortex. Since no difference in basal serum corticosterone levels was observed between the two groups, MDMA may decrease striatal type II glucocorticoid receptors via a corticosterone- independent mechanism.
Original language | English (US) |
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Pages (from-to) | 157-161 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 163 |
Issue number | 1 |
DOIs | |
State | Published - Apr 12 1989 |
Keywords
- 3,4-Methylenedioxymethamphetamine (MDMA)
- 5-Hydroxytryptamine
- Corticosterone
- Glucocorticoid receptors
- Neurotoxicity
- Striatum
ASJC Scopus subject areas
- Pharmacology