Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants

Steven M. Wolinsky*, Carla M. Wike, Bette T M Korber, Cecelia Hutto, Wade P. Parks, Lisa L. Rosenblum, Kevin J. Kunstman, Manohar R. Furtado, José L. Muñoz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

500 Scopus citations

Abstract

Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.

Original languageEnglish (US)
Pages (from-to)1134-1137
Number of pages4
JournalScience
Volume255
Issue number5048
DOIs
StatePublished - Feb 28 1992

ASJC Scopus subject areas

  • General

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