Selectivity of optical stimulation in the auditory system

Agnella D. Izzo, Jyoti Pathria, Eul Suh, Jay Walsh, Donna S Whitlon, E. Duco Jansen, Claus-Peter Richter*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

It is known that electrical current injected from cochlear implant contacts spreads within the cochlea, causing overlapping stimulation fields and possibly limiting the performance of cochlear implant users. We have investigated an alternative mechanism to stimulate auditory neurons in the gerbil cochlea using a laser, rather than electrical current. With the laser, it is possible to direct the light to a selected, known volume of tissue that is smaller than the electrically stimulated population of cells. In the present experiments, a transiently expressed transcription factor. c-FOS, was used to stain activated nerve cells. Immunohistochemical staining for c-FOS in the cochlea shows a small area of optical stimulation, which occurs directly opposite to the optical fiber. Additionally, masking data indicate that the laser can stimulate a small population of cells similar to an acoustic toneburst. Smaller populations of stimulated cells could reduce the amount of overlap in stimulation fields and allow more stimulation contacts in a neuroprothesis.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6078
DOIs
StatePublished - May 8 2006
EventPhotonic Therapeutics and Diagnostics II - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Other

OtherPhotonic Therapeutics and Diagnostics II
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Fingerprint

Acoustic Stimulation
Cochlea
stimulation
Cochlear implants
cochlea
Lasers
Cochlear Implants
selectivity
Neurons
Cells
Population
Optical Fibers
Transcription factors
Gerbillinae
lasers
Acoustics
Optical fibers
nerves
staining
Transcription Factors

Keywords

  • Cochlear implant
  • Laser
  • Neural stimulation
  • Neuroprosthesis
  • Spatial selectivity
  • Spiral ganglion cell
  • c-FOS

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Izzo, A. D., Pathria, J., Suh, E., Walsh, J., Whitlon, D. S., Duco Jansen, E., & Richter, C-P. (2006). Selectivity of optical stimulation in the auditory system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6078). [60781P] https://doi.org/10.1117/12.659743
Izzo, Agnella D. ; Pathria, Jyoti ; Suh, Eul ; Walsh, Jay ; Whitlon, Donna S ; Duco Jansen, E. ; Richter, Claus-Peter. / Selectivity of optical stimulation in the auditory system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078 2006.
@inproceedings{08d20ddbffb04a8383c5daa19db3ba68,
title = "Selectivity of optical stimulation in the auditory system",
abstract = "It is known that electrical current injected from cochlear implant contacts spreads within the cochlea, causing overlapping stimulation fields and possibly limiting the performance of cochlear implant users. We have investigated an alternative mechanism to stimulate auditory neurons in the gerbil cochlea using a laser, rather than electrical current. With the laser, it is possible to direct the light to a selected, known volume of tissue that is smaller than the electrically stimulated population of cells. In the present experiments, a transiently expressed transcription factor. c-FOS, was used to stain activated nerve cells. Immunohistochemical staining for c-FOS in the cochlea shows a small area of optical stimulation, which occurs directly opposite to the optical fiber. Additionally, masking data indicate that the laser can stimulate a small population of cells similar to an acoustic toneburst. Smaller populations of stimulated cells could reduce the amount of overlap in stimulation fields and allow more stimulation contacts in a neuroprothesis.",
keywords = "Cochlear implant, Laser, Neural stimulation, Neuroprosthesis, Spatial selectivity, Spiral ganglion cell, c-FOS",
author = "Izzo, {Agnella D.} and Jyoti Pathria and Eul Suh and Jay Walsh and Whitlon, {Donna S} and {Duco Jansen}, E. and Claus-Peter Richter",
year = "2006",
month = "5",
day = "8",
doi = "10.1117/12.659743",
language = "English (US)",
isbn = "0819461202",
volume = "6078",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

Izzo, AD, Pathria, J, Suh, E, Walsh, J, Whitlon, DS, Duco Jansen, E & Richter, C-P 2006, Selectivity of optical stimulation in the auditory system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6078, 60781P, Photonic Therapeutics and Diagnostics II, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.659743

Selectivity of optical stimulation in the auditory system. / Izzo, Agnella D.; Pathria, Jyoti; Suh, Eul; Walsh, Jay; Whitlon, Donna S; Duco Jansen, E.; Richter, Claus-Peter.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078 2006. 60781P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Selectivity of optical stimulation in the auditory system

AU - Izzo, Agnella D.

AU - Pathria, Jyoti

AU - Suh, Eul

AU - Walsh, Jay

AU - Whitlon, Donna S

AU - Duco Jansen, E.

AU - Richter, Claus-Peter

PY - 2006/5/8

Y1 - 2006/5/8

N2 - It is known that electrical current injected from cochlear implant contacts spreads within the cochlea, causing overlapping stimulation fields and possibly limiting the performance of cochlear implant users. We have investigated an alternative mechanism to stimulate auditory neurons in the gerbil cochlea using a laser, rather than electrical current. With the laser, it is possible to direct the light to a selected, known volume of tissue that is smaller than the electrically stimulated population of cells. In the present experiments, a transiently expressed transcription factor. c-FOS, was used to stain activated nerve cells. Immunohistochemical staining for c-FOS in the cochlea shows a small area of optical stimulation, which occurs directly opposite to the optical fiber. Additionally, masking data indicate that the laser can stimulate a small population of cells similar to an acoustic toneburst. Smaller populations of stimulated cells could reduce the amount of overlap in stimulation fields and allow more stimulation contacts in a neuroprothesis.

AB - It is known that electrical current injected from cochlear implant contacts spreads within the cochlea, causing overlapping stimulation fields and possibly limiting the performance of cochlear implant users. We have investigated an alternative mechanism to stimulate auditory neurons in the gerbil cochlea using a laser, rather than electrical current. With the laser, it is possible to direct the light to a selected, known volume of tissue that is smaller than the electrically stimulated population of cells. In the present experiments, a transiently expressed transcription factor. c-FOS, was used to stain activated nerve cells. Immunohistochemical staining for c-FOS in the cochlea shows a small area of optical stimulation, which occurs directly opposite to the optical fiber. Additionally, masking data indicate that the laser can stimulate a small population of cells similar to an acoustic toneburst. Smaller populations of stimulated cells could reduce the amount of overlap in stimulation fields and allow more stimulation contacts in a neuroprothesis.

KW - Cochlear implant

KW - Laser

KW - Neural stimulation

KW - Neuroprosthesis

KW - Spatial selectivity

KW - Spiral ganglion cell

KW - c-FOS

UR - http://www.scopus.com/inward/record.url?scp=33646185843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646185843&partnerID=8YFLogxK

U2 - 10.1117/12.659743

DO - 10.1117/12.659743

M3 - Conference contribution

SN - 0819461202

SN - 9780819461209

VL - 6078

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -

Izzo AD, Pathria J, Suh E, Walsh J, Whitlon DS, Duco Jansen E et al. Selectivity of optical stimulation in the auditory system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6078. 2006. 60781P https://doi.org/10.1117/12.659743