Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents

Steve R. Bull; Mustafa O. Guler; Rafael E. Bras; Thomas J. Meade; Samuel I. Stupp

doi:10.1021/nl0484898

Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents

Steve R. Bull, Mustafa O. Guler, Rafael E. Bras, Thomas J. Meade, Samuel I. Stupp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T ₁, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Nano letters
Volume	5
Issue number	1
DOIs	https://doi.org/10.1021/nl0484898
State	Published - Jan 2005

Funding

ASJC Scopus subject areas

Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Chemistry
General Materials Science

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10.1021/nl0484898

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abstract = "Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T 1, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.",

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AU - Guler, Mustafa O.

AU - Bras, Rafael E.

AU - Meade, Thomas J.

AU - Stupp, Samuel I.

PY - 2005/1

Y1 - 2005/1

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AB - Self-assembled peptide amphiphile nanofibers have been investigated for their potential use as in vivo scaffolds for tissue engineering and drug delivery applications. We report here the synthesis of magnetic resonance (MR) active peptide amphiphile molecules that self-assemble into spherical and fiber-like nanostructures, enhancing T 1, relaxation time. This new class of MR contrast agents can potentially be used to combine high-resolution three-dimensional MR fate mapping of tissue-engineered scaffolds with targeting of specific cellular receptors.

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Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents

Abstract

Funding

ASJC Scopus subject areas

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