Self-assembling and biomimetic biomaterials

Samuel I. Stupp, Elia Beniash, Jeffrey D. Hartgerink, Eli D. Sone

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


A fundamental mechanism to achieve function in biology is the interaction among nanoscale objects that have both defined shapes and surface chemistries. The most important nanostructures are, of course, proteins that can engage in molecular recognition events of high fidelity with small molecules, with segments of macromolecules, or with other proteins forming complexes that range from dimers to polymers. An interesting example of shape and surface chemical map versus function is offered by the complex known as α-hemolysin shown in Figure 22.1. This complex is formed by the self-assembly of seven polypeptide chains into a mushroom-shaped structure produced by a human pathogen, Staphylococcus aureus.

Original languageEnglish (US)
Title of host publicationBio-Implant Interface
Subtitle of host publicationImproving Biomaterials and Tissue Reactions
PublisherCRC Press
Number of pages14
ISBN (Electronic)9780203491430
ISBN (Print)9780849314742
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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