Self-assembly and mineralization of peptide-amphiphile nanofibers

J. D. Hartgerink, E. Beniash, S. I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2951 Scopus citations

Abstract

We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the long axes of the fibers. This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone.

Original languageEnglish (US)
Pages (from-to)1684-1688
Number of pages5
JournalScience
Volume294
Issue number5547
DOIs
StatePublished - Nov 23 2001

ASJC Scopus subject areas

  • General

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