Self-assembly for the synthesis of functional biomaterials

Nicholas Stephanopoulos; Julia H. Ortony; Samuel I. Stupp

doi:10.1016/j.actamat.2012.10.046

Self-assembly for the synthesis of functional biomaterials

Nicholas Stephanopoulos, Julia H. Ortony, Samuel I. Stupp^*

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

219 Scopus citations

Abstract

The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.

Original language	English (US)
Pages (from-to)	912-930
Number of pages	19
Journal	Acta Materialia
Volume	61
Issue number	3
DOIs	https://doi.org/10.1016/j.actamat.2012.10.046
State	Published - Feb 2013

Funding

Research in the authors’ laboratory described in this paper was supported by grants from the National Institutes of Health under Award #’s (5R01DE015920-07; 5R01EB003806-07), the US Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award # (DE-FG02-00ER45810), and by the National Science Foundation under Award # (DMR1006713). N.S. gratefully acknowledges support from the IIN Postdoctoral Fellowship and the Northwestern International Institute for Nanotechnology, and from a NIH Ruth L. Kirschstein NRSA postdoctoral fellowship under Award # (1F32NS077728-01A1).

Keywords

Biomaterials
Peptide amphiphiles
Peptides
Regenerative medicine
Self-assembly

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Polymers and Plastics

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10.1016/j.actamat.2012.10.046

Cite this

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title = "Self-assembly for the synthesis of functional biomaterials",

abstract = "The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.",

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Self-assembly for the synthesis of functional biomaterials

Abstract

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Keywords

ASJC Scopus subject areas

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