Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty; Tina Skorjanc; Mark Anthony Olson; Ali Trabolsi

doi:10.1039/c9cc02214g

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Original language	English (US)
Pages (from-to)	8876-8879
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	60
DOIs	https://doi.org/10.1039/c9cc02214g
State	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c9cc02214g

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title = "Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery",

abstract = "Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.",

author = "Dinesh Shetty and Tina Skorjanc and Olson, {Mark Anthony} and Ali Trabolsi",

note = "Funding Information: This work was supported by New York University Abu Dhabi (NYUAD). We thank NYUAD and the Core Technology Platforms for their generous support for the research program. The authors thank Ms Jumaanah Elhashemi for 3D cartoons. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9cc02214g",

language = "English (US)",

volume = "55",

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journal = "Chemical Communications",

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AU - Shetty, Dinesh

AU - Skorjanc, Tina

AU - Olson, Mark Anthony

AU - Trabolsi, Ali

N1 - Funding Information: This work was supported by New York University Abu Dhabi (NYUAD). We thank NYUAD and the Core Technology Platforms for their generous support for the research program. The authors thank Ms Jumaanah Elhashemi for 3D cartoons. Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

AB - Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

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U2 - 10.1039/c9cc02214g

DO - 10.1039/c9cc02214g

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JO - Chemical Communications

JF - Chemical Communications

IS - 60

ER -

Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Abstract

ASJC Scopus subject areas

UN SDGs

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