Self-assembly of stimuli-responsive imine-linked calix[4]arene nanocapsules for targeted camptothecin delivery

Dinesh Shetty, Tina Skorjanc, Mark Anthony Olson, Ali Trabolsi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.

Original languageEnglish (US)
Pages (from-to)8876-8879
Number of pages4
JournalChemical Communications
Volume55
Issue number60
DOIs
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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