Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

Wei Cheng; Lu Wang; Bingya Yang; Rong Zhang; Chun Yao; Liangqiang He; Zexu Liu; Pan Du; Kahina Hammache; Juan Wen; Huang Li; Qiang Xu; Zichun Hua

doi:10.1074/jbc.M113.533448

Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

Wei Cheng, Lu Wang, Bingya Yang, Rong Zhang, Chun Yao, Liangqiang He, Zexu Liu, Pan Du, Kahina Hammache, Juan Wen, Huang Li, Qiang Xu, Zichun Hua^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology.

Original language	English (US)
Pages (from-to)	5040-5050
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.533448
State	Published - Feb 21 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain",

abstract = "Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology.",

author = "Wei Cheng and Lu Wang and Bingya Yang and Rong Zhang and Chun Yao and Liangqiang He and Zexu Liu and Pan Du and Kahina Hammache and Juan Wen and Huang Li and Qiang Xu and Zichun Hua",

year = "2014",

month = feb,

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doi = "10.1074/jbc.M113.533448",

language = "English (US)",

volume = "289",

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T1 - Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

AU - Cheng, Wei

AU - Wang, Lu

AU - Yang, Bingya

AU - Zhang, Rong

AU - Yao, Chun

AU - He, Liangqiang

AU - Liu, Zexu

AU - Du, Pan

AU - Hammache, Kahina

AU - Wen, Juan

AU - Li, Huang

AU - Xu, Qiang

AU - Hua, Zichun

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology.

AB - Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology.

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DO - 10.1074/jbc.M113.533448

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AN - SCOPUS:84894470012

SN - 0021-9258

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SP - 5040

EP - 5050

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

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