Self-renewal and differentiation of muscle satellite cells are regulated by the fas-associated death domain

Wei Cheng, Lu Wang, Bingya Yang, Rong Zhang, Chun Yao, Liangqiang He, Zexu Liu, Pan Du, Kahina Hammache, Juan Wen, Huang Li, Qiang Xu, Zichun Hua*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: The balance between self-renewal and differentiation in muscle stem cells is critical for tissue homeostasis. Results: Fas-associated death domain (FADD) phosphorylation mutation regulates muscle satellite cell cycle progression, inhibits muscle stem cell differentiation, and promotes muscle stem cell self-renewal. Conclusion: FADD regulates muscle stem cell fate decisions. Significance: The characterization of proteins involved in fate decisions in muscle stem cells is crucial for muscle stem cell biology.

Original languageEnglish (US)
Pages (from-to)5040-5050
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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