Self-replication vs. reactive binary complexes - Manipulating recognition-mediated cycloadditions by simple structural modifications

Russell J. Pearson, Eleftherios Kassianidis, Alexandra M.Z. Slawin, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The rate of reaction and the selectivity of a Diels - Alder cycloaddition between a furan and a maleimide can be enhanced by the introduction of complementary recognition sites on the reactant species. Subtle manipulation of other structural elements allows the generation of the observed rate enhancements and selectivities through either self-replication or formation of a pre-reactivc binary complex.

Original languageEnglish (US)
Pages (from-to)3434-3441
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume2
Issue number23
DOIs
StatePublished - Dec 7 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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