Self-starvation and rewarding brain stimulation: Effects of chlorpromazine and pentobarbital

Aryeh Routtenberg*, George C. Bulloch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Given the choice between rewarding brain stimulation and food, albino rats with electrodes placed in or near the medial aspect of the medial forebrain bundle (M-MFB) ignored food and self-stimulated. Subjects with electrodes placed in the lateral aspect of MFB (L-MFB) also self-stimulated, but did not ignore food. In M-MFB animals pretreated with chlorpromazine (CPZ, 2 mg/kg, ip), self-stimulation was reduced and self-starvation was attenuated. When the same subjects were pretreated with pentobarbital (PENT, 8 mg/kg, ip), self-stimulation was not reduced, but self-starvation was attenuated.

Original languageEnglish (US)
Pages (from-to)83-94
Number of pages12
JournalLearning and Motivation
Issue number1
StatePublished - Feb 1971

ASJC Scopus subject areas

  • Health(social science)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Education
  • Developmental and Educational Psychology


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