Given the choice between rewarding brain stimulation and food, albino rats with electrodes placed in or near the medial aspect of the medial forebrain bundle (M-MFB) ignored food and self-stimulated. Subjects with electrodes placed in the lateral aspect of MFB (L-MFB) also self-stimulated, but did not ignore food. In M-MFB animals pretreated with chlorpromazine (CPZ, 2 mg/kg, ip), self-stimulation was reduced and self-starvation was attenuated. When the same subjects were pretreated with pentobarbital (PENT, 8 mg/kg, ip), self-stimulation was not reduced, but self-starvation was attenuated.
ASJC Scopus subject areas
- Health(social science)
- Neuropsychology and Physiological Psychology
- Experimental and Cognitive Psychology
- Developmental and Educational Psychology