"Self-starvation" in activity wheels: Developmental and chlorpromazine interactions

Donald J. Woods*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Conducted 4 experiments with a total of 70 30-45 and 22 70-90 day old male albino Sprague-Dawley rats. Adult Ss on a food-deprivation schedule showed increased running in activity wheels and a paradoxical depression of food intake. This "self-starvation" effect was markedly potentiated in younger Ss, which, relative to controls, ran more and sustained greater weight loss than did older Ss. Chlorpromazine (a) reversed the self-starvation syndrome by depressing the activity and alleviating weight loss of the older Ss, and (b) exacerbated self-starvation with younger Ss. It is concluded that 30-45 day old Ss reacted to 23-hr deprivation with a severe stress response, perhaps related to the failure of incompletely developed neural and endocrine mechanisms to modulate the reaction to the self-starvation situation. (19 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)84-93
Number of pages10
JournalJournal of Comparative and Physiological Psychology
Volume76
Issue number1
DOIs
StatePublished - Jun 1 1971

Keywords

  • chlorpromazine, increased running in activity wheels &
  • paradoxical depression of food intake, 30-45 vs. 70-90 day old rat on food-deprivation schedule

ASJC Scopus subject areas

  • Medicine(all)

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