Selfing is the safest sex for caenorhabditis tropicalis

Luke M. Noble; John Yuen; Lewis Stevens; Nicolas Moya; Riaad Persaud; Marc Moscatelli; Jacqueline Jackson; Christian Braendle; Erik C. Andersen; Hannah S. Seidel; Matthew V. Rockman

doi:10.1101/2020.08.07.242032

Selfing is the safest sex for caenorhabditis tropicalis

Luke M. Noble^*, John Yuen, Lewis Stevens, Nicolas Moya, Riaad Persaud, Marc Moscatelli, Jacqueline Jackson, Christian Braendle, Erik C. Andersen, Hannah S. Seidel, Matthew V. Rockman

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

Abstract

Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, C. tropicalis is the least genetically diverse and most afflicted by outbreeding depression. We generated a chromosomal-scale genome for C. tropicalis and surveyed global diversity. Population structure is very strong, and islands of extreme divergence punctuate a genomic background that is highly homogeneous around the globe. Outbreeding depression in the laboratory is caused largely by multiple gene drive elements, genetically consistent with maternal toxin/zygotic antidote systems. Driver loci harbor novel and duplicated genes, and their activity is modified by mito-nuclear background. Segregating drivers dramatically reduce fitness, and simulations show that selfing limits their spread. Frequent selfing in C. tropicalis may therefore be a strategy to avoid drive-mediated outbreeding depression.

Original language	English (US)
Journal	Unknown Journal
DOIs	https://doi.org/10.1101/2020.08.07.242032
State	Published - Aug 7 2020

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Immunology and Microbiology(all)
Neuroscience(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Selfing is the safest sex for caenorhabditis tropicalis",

abstract = "Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, C. tropicalis is the least genetically diverse and most afflicted by outbreeding depression. We generated a chromosomal-scale genome for C. tropicalis and surveyed global diversity. Population structure is very strong, and islands of extreme divergence punctuate a genomic background that is highly homogeneous around the globe. Outbreeding depression in the laboratory is caused largely by multiple gene drive elements, genetically consistent with maternal toxin/zygotic antidote systems. Driver loci harbor novel and duplicated genes, and their activity is modified by mito-nuclear background. Segregating drivers dramatically reduce fitness, and simulations show that selfing limits their spread. Frequent selfing in C. tropicalis may therefore be a strategy to avoid drive-mediated outbreeding depression.",

author = "Noble, {Luke M.} and John Yuen and Lewis Stevens and Nicolas Moya and Riaad Persaud and Marc Moscatelli and Jacqueline Jackson and Christian Braendle and Andersen, {Erik C.} and Seidel, {Hannah S.} and Rockman, {Matthew V.}",

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year = "2020",

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doi = "10.1101/2020.08.07.242032",

language = "English (US)",

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AU - Noble, Luke M.

AU - Yuen, John

AU - Stevens, Lewis

AU - Moya, Nicolas

AU - Persaud, Riaad

AU - Moscatelli, Marc

AU - Jackson, Jacqueline

AU - Braendle, Christian

AU - Andersen, Erik C.

AU - Seidel, Hannah S.

AU - Rockman, Matthew V.

N1 - Publisher Copyright: The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8/7

Y1 - 2020/8/7

N2 - Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, C. tropicalis is the least genetically diverse and most afflicted by outbreeding depression. We generated a chromosomal-scale genome for C. tropicalis and surveyed global diversity. Population structure is very strong, and islands of extreme divergence punctuate a genomic background that is highly homogeneous around the globe. Outbreeding depression in the laboratory is caused largely by multiple gene drive elements, genetically consistent with maternal toxin/zygotic antidote systems. Driver loci harbor novel and duplicated genes, and their activity is modified by mito-nuclear background. Segregating drivers dramatically reduce fitness, and simulations show that selfing limits their spread. Frequent selfing in C. tropicalis may therefore be a strategy to avoid drive-mediated outbreeding depression.

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