Abstract
This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 237-250 |
| Number of pages | 14 |
| Journal | Brain and Language |
| Volume | 120 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2012 |
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Keywords
- Cortical thickness
- FreeSurfer
- Naming deficits in primary progressive aphasia
- Primary progressive aphasia
- Semantic interference
- Word interference paradigms
ASJC Scopus subject areas
- Language and Linguistics
- Experimental and Cognitive Psychology
- Linguistics and Language
- Cognitive Neuroscience
- Speech and Hearing
Cite this
}
Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA). / Thompson, Cynthia K.; Cho, Soojin; Price, Charis; Wieneke, Christina; Bonakdarpour, Borna; Rogalski, Emily; Weintraub, Sandra; Mesulam, M. Marsel.
In: Brain and Language, Vol. 120, No. 3, 01.03.2012, p. 237-250.Research output: Contribution to journal › Article
TY - JOUR
T1 - Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)
AU - Thompson, Cynthia K.
AU - Cho, Soojin
AU - Price, Charis
AU - Wieneke, Christina
AU - Bonakdarpour, Borna
AU - Rogalski, Emily
AU - Weintraub, Sandra
AU - Mesulam, M. Marsel
PY - 2012/3/1
Y1 - 2012/3/1
N2 - This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.
AB - This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.
KW - Cortical thickness
KW - FreeSurfer
KW - Naming deficits in primary progressive aphasia
KW - Primary progressive aphasia
KW - Semantic interference
KW - Word interference paradigms
UR - http://www.scopus.com/inward/record.url?scp=84858005940&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858005940&partnerID=8YFLogxK
U2 - 10.1016/j.bandl.2011.11.003
DO - 10.1016/j.bandl.2011.11.003
M3 - Article
C2 - 22244508
AN - SCOPUS:84858005940
VL - 120
SP - 237
EP - 250
JO - Brain and Language
JF - Brain and Language
SN - 0093-934X
IS - 3
ER -