Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)

Cynthia K. Thompson; Soojin Cho; Charis Price; Christina Wieneke; Borna Bonakdarpour; Emily Rogalski; Sandra Weintraub; M. Marsel Mesulam

doi:10.1016/j.bandl.2011.11.003

Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)

Cynthia K. Thompson^*, Soojin Cho, Charis Price, Christina Wieneke, Borna Bonakdarpour, Emily Rogalski, Sandra Weintraub, M. Marsel Mesulam

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.

Original language	English (US)
Pages (from-to)	237-250
Number of pages	14
Journal	Brain and Language
Volume	120
Issue number	3
DOIs	https://doi.org/10.1016/j.bandl.2011.11.003
State	Published - Mar 2012

Funding

This research was supported by the NIH Grants: RO1DC01948 (C.K. Thompson), R01DC008551(M. Mesulam), and AG13854 (Alzheimer’s Disease Core Center), Northwestern University. The authors wish to thank Dr. Darin Cobia for his assistance with data analysis. We also acknowledge the Center for Advanced MRI (CAMRI) at Northwestern University for their scanning support.

Keywords

Cortical thickness
FreeSurfer
Naming deficits in primary progressive aphasia
Primary progressive aphasia
Semantic interference
Word interference paradigms

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Speech and Hearing
Cognitive Neuroscience
Language and Linguistics
Linguistics and Language

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10.1016/j.bandl.2011.11.003

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title = "Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)",

abstract = "This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.",

keywords = "Cortical thickness, FreeSurfer, Naming deficits in primary progressive aphasia, Primary progressive aphasia, Semantic interference, Word interference paradigms",

author = "Thompson, {Cynthia K.} and Soojin Cho and Charis Price and Christina Wieneke and Borna Bonakdarpour and Emily Rogalski and Sandra Weintraub and Mesulam, {M. Marsel}",

note = "Funding Information: This research was supported by the NIH Grants: RO1DC01948 (C.K. Thompson), R01DC008551(M. Mesulam), and AG13854 (Alzheimer{\textquoteright}s Disease Core Center), Northwestern University. The authors wish to thank Dr. Darin Cobia for his assistance with data analysis. We also acknowledge the Center for Advanced MRI (CAMRI) at Northwestern University for their scanning support.",

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AU - Bonakdarpour, Borna

AU - Rogalski, Emily

AU - Weintraub, Sandra

AU - Mesulam, M. Marsel

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N2 - This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.

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Semantic interference during object naming in agrammatic and logopenic primary progressive aphasia (PPA)

Abstract

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Keywords

ASJC Scopus subject areas

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