Abstract
This study examined the time course of object naming in 21 individuals with primary progressive aphasia (PPA) (8 agrammatic (PPA-G); 13 logopenic (PPA-L)) and healthy age-matched speakers (n=17) using a semantic interference paradigm with related and unrelated interfering stimuli presented at stimulus onset asynchronies (SOAs) of -1000, -500, -100 and 0. ms. Results showed semantic interference (SI) (i.e. significantly slower RTs in related compared to unrelated conditions) for all groups at -500, -100 and 0. ms, indicating timely spreading activation to semantic competitors. However, both PPA groups showed a greater magnitude of SI than normal across SOAs. The PPA-L group and six PPA-G participants also evinced SI at -1000. ms, suggesting an abnormal time course of semantic interference resolution, and concomitant left hemisphere cortical atrophy in brain regions associated with semantic processing. These subtle semantic mapping impairments in non-semantic variants of PPA may contribute to the anomia of these patients.
Original language | English (US) |
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Pages (from-to) | 237-250 |
Number of pages | 14 |
Journal | Brain and Language |
Volume | 120 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2012 |
Keywords
- Cortical thickness
- FreeSurfer
- Naming deficits in primary progressive aphasia
- Primary progressive aphasia
- Semantic interference
- Word interference paradigms
ASJC Scopus subject areas
- Language and Linguistics
- Experimental and Cognitive Psychology
- Linguistics and Language
- Cognitive Neuroscience
- Speech and Hearing