Sensitivity Analysis in Clinical Trial Simulation at Sas Institute

Wendy Xi Jiang, Bahar Biller, Jim Box, Barry L. Nelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Clinical trial enrollment is expensive, important, and subject to many uncertainties. Simulation captures these uncertainties, so SAS® Institute created the Clinical Trial Enrollment Simulator (CTrES) as a tool specifically for enrollment planning. However, simulation provides no mathematical expression from which to extract sensitivity measures that are critical for problem diagnosis and management. This paper describes sensitivity analysis technology created for CTrES requiring only the output data obtained from simulation of the base scenario, and demonstrates it on a realistic enrollment planning problem for the United States.

Original languageEnglish (US)
Title of host publication2021 Winter Simulation Conference, WSC 2021
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665433112
StatePublished - 2021
Event2021 Winter Simulation Conference, WSC 2021 - Phoenix, United States
Duration: Dec 12 2021Dec 15 2021

Publication series

NameProceedings - Winter Simulation Conference
ISSN (Print)0891-7736


Conference2021 Winter Simulation Conference, WSC 2021
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Software
  • Modeling and Simulation
  • Computer Science Applications


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