Sensitization to morphine induced by viral-mediated gene transfer

William A. Carlezon, Virginia A. Boundy, Colin N. Haile, Sarah B. Lane, Robert G. Kalb, Rachael L. Neve, Eric J. Nestler*

*Corresponding author for this work

Research output: Contribution to journalArticle

234 Scopus citations

Abstract

Repeated administration of morphine sensitizes animals to the stimulant and rewarding properties of the drug. It also selectively increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area, a midbrain region implicated in morphine action. By viral- mediated gene transfer, a causal relation is shown between these behavioral and biochemical adaptations: Morphine's stimulant and rewarding properties are intensified after microinjections of a viral vector expressing GluR1 into the ventral tegmental area. These results confirm the importance of AMPA receptors in morphine action and demonstrate specific locomotor and motivational adaptations resulting from altered expression of a single localized gene product.

Original languageEnglish (US)
Pages (from-to)812-814
Number of pages3
JournalScience
Volume277
Issue number5327
DOIs
StatePublished - Aug 8 1997

ASJC Scopus subject areas

  • General

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    Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997). Sensitization to morphine induced by viral-mediated gene transfer. Science, 277(5327), 812-814. https://doi.org/10.1126/science.277.5327.812