TY - JOUR
T1 - Sensitization to mouse and cockroach allergens and asthma morbidity in urban minority youth
T2 - Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II)
AU - Fishbein, Anna B.
AU - Lee, Todd A.
AU - Cai, Miao
AU - Oh, Sam S.
AU - Eng, Celeste
AU - Hu, Donglei
AU - Huntsman, Scott
AU - Farber, Harold J.
AU - Serebrisky, Denise
AU - Silverberg, Jonathan
AU - Williams, L. Keoki
AU - Seibold, Max A.
AU - Sen, Saunak
AU - Borrell, Luisa N.
AU - Avila, Pedro
AU - Rodriguez-Cintron, William
AU - Rodriguez-Santana, Jose R.
AU - Burchard, Esteban G.
AU - Kumar, Rajesh
N1 - Funding Information:
Funding Sources: This study was supported in part by grants ES015794, AI077439, HL088133, HL078885, CA113710, AI079139, HL004464, HL104608, AI061774, HL079055, DK064695, and M01-RR00188; HHSN26120080001E; and MD006902 from the National Institutes of Health; the Flight Attendant Medical Research Institute; an Robert Wood Johnson Foundation Amos Medical Faculty Development Award (Dr Burchard); the Sandler Foundation; the American Asthma Foundation (Dr Burchard); and an Ernest S. Bazley grant (Dr Avila). In addition, the research reported in this publication was supported by award P60MD006902 from the National Institute on Minority Health and Health Disparities of the National Institutes of Health.
Publisher Copyright:
© 2016 American College of Allergy, Asthma & Immunology
PY - 2016/7
Y1 - 2016/7
N2 - Background Pest allergen sensitization is associated with asthma morbidity in urban youth but minimally explored in Latino populations. Specifically, the effect of mouse sensitization on the risk of asthma exacerbation has been unexplored in Latino subgroups. Objective To evaluate whether pest allergen sensitization is a predictor of asthma exacerbations and poor asthma control in urban minority children with asthma. Methods Latino and African American children (8–21 years old) with asthma were recruited from 4 sites across the United States. Logistic regression models evaluated the association of mouse or cockroach sensitization with asthma-related acute care visits or hospitalizations. Results A total of 1,992 children with asthma in the Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II) cohorts were studied. Asthmatic children from New York had the highest rate of pest allergen sensitization (42% mouse, 56% cockroach), with the lowest rate in San Francisco (4% mouse, 8% cockroach). Mouse sensitization, more than cockroach, was associated with increased odds of acute care visits (adjusted odds ratio [aOR], 1.47; 95% CI, 1.07–2.03) or hospitalizations (aOR, 3.07; 95% CI, 1.81–5.18), even after controlling for self-reported race and site of recruitment. In stratified analyses, Mexican youth sensitized to mouse allergen did not have higher odds of asthma exacerbation. Other Latino and Puerto Rican youth sensitized to mouse had higher odds of hospitalization for asthma (aORs, 4.57 [95% CI, 1.86–11.22] and 10.01 [95% CI, 1.77–56.6], respectively) but not emergency department visits. Conclusion Pest allergen sensitization is associated with a higher odds of asthma exacerbations in urban minority youth. Puerto Rican and Other Latino youth sensitized to mouse were more likely to have asthma-related hospitalizations than Mexican youth.
AB - Background Pest allergen sensitization is associated with asthma morbidity in urban youth but minimally explored in Latino populations. Specifically, the effect of mouse sensitization on the risk of asthma exacerbation has been unexplored in Latino subgroups. Objective To evaluate whether pest allergen sensitization is a predictor of asthma exacerbations and poor asthma control in urban minority children with asthma. Methods Latino and African American children (8–21 years old) with asthma were recruited from 4 sites across the United States. Logistic regression models evaluated the association of mouse or cockroach sensitization with asthma-related acute care visits or hospitalizations. Results A total of 1,992 children with asthma in the Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II) cohorts were studied. Asthmatic children from New York had the highest rate of pest allergen sensitization (42% mouse, 56% cockroach), with the lowest rate in San Francisco (4% mouse, 8% cockroach). Mouse sensitization, more than cockroach, was associated with increased odds of acute care visits (adjusted odds ratio [aOR], 1.47; 95% CI, 1.07–2.03) or hospitalizations (aOR, 3.07; 95% CI, 1.81–5.18), even after controlling for self-reported race and site of recruitment. In stratified analyses, Mexican youth sensitized to mouse allergen did not have higher odds of asthma exacerbation. Other Latino and Puerto Rican youth sensitized to mouse had higher odds of hospitalization for asthma (aORs, 4.57 [95% CI, 1.86–11.22] and 10.01 [95% CI, 1.77–56.6], respectively) but not emergency department visits. Conclusion Pest allergen sensitization is associated with a higher odds of asthma exacerbations in urban minority youth. Puerto Rican and Other Latino youth sensitized to mouse were more likely to have asthma-related hospitalizations than Mexican youth.
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U2 - 10.1016/j.anai.2016.05.004
DO - 10.1016/j.anai.2016.05.004
M3 - Article
C2 - 27238578
AN - SCOPUS:84970023634
SN - 1081-1206
VL - 117
SP - 43-49.e1
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 1
ER -