Sensitization to mouse and cockroach allergens and asthma morbidity in urban minority youth: Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II)

Anna B. Fishbein*, Todd A. Lee, Miao Cai, Sam S. Oh, Celeste Eng, Donglei Hu, Scott Huntsman, Harold J. Farber, Denise Serebrisky, Jonathan Silverberg, L. Keoki Williams, Max A. Seibold, Saunak Sen, Luisa N. Borrell, Pedro Avila, William Rodriguez-Cintron, Jose R. Rodriguez-Santana, Esteban G. Burchard, Rajesh Kumar

*Corresponding author for this work

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9 Scopus citations

Abstract

Background Pest allergen sensitization is associated with asthma morbidity in urban youth but minimally explored in Latino populations. Specifically, the effect of mouse sensitization on the risk of asthma exacerbation has been unexplored in Latino subgroups. Objective To evaluate whether pest allergen sensitization is a predictor of asthma exacerbations and poor asthma control in urban minority children with asthma. Methods Latino and African American children (8–21 years old) with asthma were recruited from 4 sites across the United States. Logistic regression models evaluated the association of mouse or cockroach sensitization with asthma-related acute care visits or hospitalizations. Results A total of 1,992 children with asthma in the Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II) cohorts were studied. Asthmatic children from New York had the highest rate of pest allergen sensitization (42% mouse, 56% cockroach), with the lowest rate in San Francisco (4% mouse, 8% cockroach). Mouse sensitization, more than cockroach, was associated with increased odds of acute care visits (adjusted odds ratio [aOR], 1.47; 95% CI, 1.07–2.03) or hospitalizations (aOR, 3.07; 95% CI, 1.81–5.18), even after controlling for self-reported race and site of recruitment. In stratified analyses, Mexican youth sensitized to mouse allergen did not have higher odds of asthma exacerbation. Other Latino and Puerto Rican youth sensitized to mouse had higher odds of hospitalization for asthma (aORs, 4.57 [95% CI, 1.86–11.22] and 10.01 [95% CI, 1.77–56.6], respectively) but not emergency department visits. Conclusion Pest allergen sensitization is associated with a higher odds of asthma exacerbations in urban minority youth. Puerto Rican and Other Latino youth sensitized to mouse were more likely to have asthma-related hospitalizations than Mexican youth.

Original languageEnglish (US)
Pages (from-to)43-49.e1
JournalAnnals of Allergy, Asthma and Immunology
Volume117
Issue number1
DOIs
StatePublished - Jul 2016

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Fishbein, A. B., Lee, T. A., Cai, M., Oh, S. S., Eng, C., Hu, D., Huntsman, S., Farber, H. J., Serebrisky, D., Silverberg, J., Williams, L. K., Seibold, M. A., Sen, S., Borrell, L. N., Avila, P., Rodriguez-Cintron, W., Rodriguez-Santana, J. R., Burchard, E. G., & Kumar, R. (2016). Sensitization to mouse and cockroach allergens and asthma morbidity in urban minority youth: Genes-environments and Admixture in Latino American (GALA-II) and Study of African-Americans, Asthma, Genes, and Environments (SAGE-II). Annals of Allergy, Asthma and Immunology, 117(1), 43-49.e1. https://doi.org/10.1016/j.anai.2016.05.004