Sensitized photodecomposition of organic bisphosphonates by singlet oxygen

Kenneth Hanson, Dennis L. Ashford, Javier J. Concepcion, Robert A. Binstead, Sohrab Habibi, Hanlin Luo, Christopher R K Glasson, Joseph L. Templeton, Thomas J. Meyer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

During efforts to stabilize metal oxide bound chromophores for photoelectrochemical applications, a novel photochemical reaction has been discovered. In the reaction, the bisphosphonate functional groups -C(PO 3H2)2(OH) in the metal complex [Ru(bpy) 2(4,4′-(C(OH)(PO3H2)2bpy)] 2+ are converted into -COOH and H3PO4. The reaction occurs by sensitized formation of 1O2 by the lowest metal-to-ligand charge transfer excited state(s) of [Ru(bpy) 2(4,4′-(C(PO3H2)2(OH)) 2(bpy))]2+* followed by 1O2 oxidation of the bisphosphonate substituent. A related reaction occurs for the bisphosphonate-based drug, risedronic acid, in the presence of O2, light, and a singlet oxygen sensitizer ([Ru(bpy)3]2+ or Rose Bengal).

Original languageEnglish (US)
Pages (from-to)16975-16978
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number41
DOIs
StatePublished - Oct 17 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Sensitized photodecomposition of organic bisphosphonates by singlet oxygen'. Together they form a unique fingerprint.

Cite this