Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

Kimberly A. Smith, Paul T Schumacker*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

When lung cells experience hypoxia, the functional response, termed hypoxic pulmonary vasoconstriction, activates a multitude of pathways with the goal of optimizing gas exchange. While previously controversial, overwhelming evidence now suggests that increased reactive oxygen species – produced at complex III of the mitochondrial electron transport chain and released into the intermembrane space – is the cellular oxygen signal responsible for triggering hypoxic pulmonary vasoconstriction. The increased reactive oxygen species (ROS) activate many downstream targets that ultimately lead to increased intracellular ionized calcium concentration and contraction of pulmonary arterial smooth muscle cells. While the specific targets of ROS signals are not completely understood, it is clear that this signalling pathway is critical for development and for normal lung function in newborns and adults. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)1033-1043
Number of pages11
JournalJournal of Physiology
Volume597
Issue number4
DOIs
StatePublished - Feb 15 2019

Fingerprint

Vasoconstriction
Reactive Oxygen Species
Lung
Cell Hypoxia
Critical Pathways
Electron Transport Complex III
Smooth Muscle Myocytes
Gases
Oxygen
Calcium

Keywords

  • hypoxia
  • mitochondria
  • pulmonary circulation
  • pulmonary hypertension
  • redox signaling

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "When lung cells experience hypoxia, the functional response, termed hypoxic pulmonary vasoconstriction, activates a multitude of pathways with the goal of optimizing gas exchange. While previously controversial, overwhelming evidence now suggests that increased reactive oxygen species – produced at complex III of the mitochondrial electron transport chain and released into the intermembrane space – is the cellular oxygen signal responsible for triggering hypoxic pulmonary vasoconstriction. The increased reactive oxygen species (ROS) activate many downstream targets that ultimately lead to increased intracellular ionized calcium concentration and contraction of pulmonary arterial smooth muscle cells. While the specific targets of ROS signals are not completely understood, it is clear that this signalling pathway is critical for development and for normal lung function in newborns and adults. (Figure presented.).",
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Sensors and signals : the role of reactive oxygen species in hypoxic pulmonary vasoconstriction. / Smith, Kimberly A.; Schumacker, Paul T.

In: Journal of Physiology, Vol. 597, No. 4, 15.02.2019, p. 1033-1043.

Research output: Contribution to journalArticle

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