Sensory sensitivity and symptom severity represent unique dimensions of chronic pain

A MAPP Research Network study

Andrew Schrepf, David A. Williams, Robert Gallop, Bruce D. Naliboff, Neil Basu, Chelsea Kaplan, Daniel E. Harper, J. Richard Landis, J. Quentin Clemens, Eric Strachan, James W Griffith, Niloofar Afari, Afton Hassett, Michel A. Pontari, Daniel J. Clauw, Steven E. Harte*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chronic overlapping pain conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This "centralized pain" phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here, we used 3 cohorts, including patients with urologic chronic pelvic pain syndrome, a mixed pain cohort with other COPCs, and healthy individuals (total n 5 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Using exploratory and confirmatory factor analysis, we identified 2 general factors in all 3 cohorts, one characterized by a broad increased sensitivity to internal somatic sensations,environmental stimuli, and diffuse pain, termed Generalized Sensory Sensitivity, and one characterized by constitutional symptoms-Sleep, Pain, Affect, Cognition, Energy (SPACE). Longitudinal analyses in the urologic chronic pelvic pain syndrome cohort found the same 2-factor structure at month 6 and 1 year, suggesting that the 2-factor structure is reproducible over time. In secondary analyses, we found that Generalized Sensory Sensitivity particularly is associated with the presence of comorbid COPCs, whereas SPACE shows modest associations with measures of disability and urinary symptoms. These factors may represent an important and distinct continuum of symptoms that are indicative of the centralized pain phenotype at high levels. Future research of COPCs should accommodate the measurement of each factor.

Original languageEnglish (US)
Pages (from-to)2002-2011
Number of pages10
JournalPain
Volume159
Issue number10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Chronic Pain
Pain
Research
Pelvic Pain
Cognition
Sleep
Phenotype
Statistical Factor Analysis
Fatigue
Hypersensitivity
Central Nervous System

Keywords

  • Central nervous system sensitization
  • Factor analysis
  • Fibromyalgia
  • Interoception
  • Interstitial cystitis/painful bladder syndrome
  • statistical

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Schrepf, A., Williams, D. A., Gallop, R., Naliboff, B. D., Basu, N., Kaplan, C., ... Harte, S. E. (2018). Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: A MAPP Research Network study. Pain, 159(10), 2002-2011. https://doi.org/10.1097/j.pain.0000000000001299
Schrepf, Andrew ; Williams, David A. ; Gallop, Robert ; Naliboff, Bruce D. ; Basu, Neil ; Kaplan, Chelsea ; Harper, Daniel E. ; Richard Landis, J. ; Quentin Clemens, J. ; Strachan, Eric ; Griffith, James W ; Afari, Niloofar ; Hassett, Afton ; Pontari, Michel A. ; Clauw, Daniel J. ; Harte, Steven E. / Sensory sensitivity and symptom severity represent unique dimensions of chronic pain : A MAPP Research Network study. In: Pain. 2018 ; Vol. 159, No. 10. pp. 2002-2011.
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Schrepf, A, Williams, DA, Gallop, R, Naliboff, BD, Basu, N, Kaplan, C, Harper, DE, Richard Landis, J, Quentin Clemens, J, Strachan, E, Griffith, JW, Afari, N, Hassett, A, Pontari, MA, Clauw, DJ & Harte, SE 2018, 'Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: A MAPP Research Network study', Pain, vol. 159, no. 10, pp. 2002-2011. https://doi.org/10.1097/j.pain.0000000000001299

Sensory sensitivity and symptom severity represent unique dimensions of chronic pain : A MAPP Research Network study. / Schrepf, Andrew; Williams, David A.; Gallop, Robert; Naliboff, Bruce D.; Basu, Neil; Kaplan, Chelsea; Harper, Daniel E.; Richard Landis, J.; Quentin Clemens, J.; Strachan, Eric; Griffith, James W; Afari, Niloofar; Hassett, Afton; Pontari, Michel A.; Clauw, Daniel J.; Harte, Steven E.

In: Pain, Vol. 159, No. 10, 01.01.2018, p. 2002-2011.

Research output: Contribution to journalArticle

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T1 - Sensory sensitivity and symptom severity represent unique dimensions of chronic pain

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AU - Schrepf, Andrew

AU - Williams, David A.

AU - Gallop, Robert

AU - Naliboff, Bruce D.

AU - Basu, Neil

AU - Kaplan, Chelsea

AU - Harper, Daniel E.

AU - Richard Landis, J.

AU - Quentin Clemens, J.

AU - Strachan, Eric

AU - Griffith, James W

AU - Afari, Niloofar

AU - Hassett, Afton

AU - Pontari, Michel A.

AU - Clauw, Daniel J.

AU - Harte, Steven E.

PY - 2018/1/1

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N2 - Chronic overlapping pain conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This "centralized pain" phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here, we used 3 cohorts, including patients with urologic chronic pelvic pain syndrome, a mixed pain cohort with other COPCs, and healthy individuals (total n 5 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Using exploratory and confirmatory factor analysis, we identified 2 general factors in all 3 cohorts, one characterized by a broad increased sensitivity to internal somatic sensations,environmental stimuli, and diffuse pain, termed Generalized Sensory Sensitivity, and one characterized by constitutional symptoms-Sleep, Pain, Affect, Cognition, Energy (SPACE). Longitudinal analyses in the urologic chronic pelvic pain syndrome cohort found the same 2-factor structure at month 6 and 1 year, suggesting that the 2-factor structure is reproducible over time. In secondary analyses, we found that Generalized Sensory Sensitivity particularly is associated with the presence of comorbid COPCs, whereas SPACE shows modest associations with measures of disability and urinary symptoms. These factors may represent an important and distinct continuum of symptoms that are indicative of the centralized pain phenotype at high levels. Future research of COPCs should accommodate the measurement of each factor.

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