SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson; John P. Devincenzo; Eric A.F. Simões; Leonard R. Krilov; Michael L. Forbes; Pia S. Pannaraj; Claudia M. Espinosa; Robert C. Welliver; Leslie I. Wolkoff; Ram Yogev; Paul A. Checchia; Joseph B. Domachowske; Natasha Halasa; Scott J. McBride; Veena R. Kumar; Kimmie K. McLaurin; Christopher P. Rizzo; Christopher S. Ambrose

doi:10.1055/s-0039-1681014

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson, John P. Devincenzo, Eric A.F. Simões, Leonard R. Krilov, Michael L. Forbes, Pia S. Pannaraj, Claudia M. Espinosa, Robert C. Welliver, Leslie I. Wolkoff, Ram Yogev, Paul A. Checchia, Joseph B. Domachowske, Natasha Halasa, Scott J. McBride, Veena R. Kumar, Kimmie K. McLaurin, Christopher P. Rizzo^*, Christopher S. Ambrose

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. Results Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.

Original language	English (US)
Pages (from-to)	421-429
Number of pages	9
Journal	American journal of perinatology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1055/s-0039-1681014
State	Published - Mar 1 2020

Funding

This study was sponsored by AstraZeneca. Editorial support was provided by The Lockwood Group, which was in accordance with Good Publication Practice (GPP3) guidelines and funded by AstraZeneca.

Keywords

hospitalizations
immunoprophylaxis
infants
palivizumab
respiratory syncytial virus

ASJC Scopus subject areas

Obstetrics and Gynecology
Pediatrics, Perinatology, and Child Health

Access to Document

10.1055/s-0039-1681014

Cite this

Anderson, E. J., Devincenzo, J. P., Simões, E. A. F., Krilov, L. R., Forbes, M. L., Pannaraj, P. S., Espinosa, C. M., Welliver, R. C., Wolkoff, L. I., Yogev, R., Checchia, P. A., Domachowske, J. B., Halasa, N., McBride, S. J., Kumar, V. R., McLaurin, K. K., Rizzo, C. P., & Ambrose, C. S. (2020). SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. American journal of perinatology, 37(4), 421-429. https://doi.org/10.1055/s-0039-1681014

@article{337a9913523047f1a2271266ca45d334,

title = "SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis",

abstract = "Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. Results Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.",

keywords = "hospitalizations, immunoprophylaxis, infants, palivizumab, respiratory syncytial virus",

author = "Anderson, {Evan J.} and Devincenzo, {John P.} and Sim{\~o}es, {Eric A.F.} and Krilov, {Leonard R.} and Forbes, {Michael L.} and Pannaraj, {Pia S.} and Espinosa, {Claudia M.} and Welliver, {Robert C.} and Wolkoff, {Leslie I.} and Ram Yogev and Checchia, {Paul A.} and Domachowske, {Joseph B.} and Natasha Halasa and McBride, {Scott J.} and Kumar, {Veena R.} and McLaurin, {Kimmie K.} and Rizzo, {Christopher P.} and Ambrose, {Christopher S.}",

note = "Publisher Copyright: {\textcopyright} 2020 by Thieme Medical Publishers, Inc.",

year = "2020",

month = mar,

day = "1",

doi = "10.1055/s-0039-1681014",

language = "English (US)",

volume = "37",

pages = "421--429",

journal = "American journal of perinatology",

issn = "0735-1631",

publisher = "Thieme Medical Publishers, Inc.",

number = "4",

}

Anderson, EJ, Devincenzo, JP, Simões, EAF, Krilov, LR, Forbes, ML, Pannaraj, PS, Espinosa, CM, Welliver, RC, Wolkoff, LI, Yogev, R, Checchia, PA, Domachowske, JB, Halasa, N, McBride, SJ, Kumar, VR, McLaurin, KK, Rizzo, CP & Ambrose, CS 2020, 'SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis', American journal of perinatology, vol. 37, no. 4, pp. 421-429. https://doi.org/10.1055/s-0039-1681014

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis. / Anderson, Evan J.; Devincenzo, John P.; Simões, Eric A.F. et al.
In: American journal of perinatology, Vol. 37, No. 4, 01.03.2020, p. 421-429.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - SENTINEL1

T2 - Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

AU - Anderson, Evan J.

AU - Devincenzo, John P.

AU - Simões, Eric A.F.

AU - Krilov, Leonard R.

AU - Forbes, Michael L.

AU - Pannaraj, Pia S.

AU - Espinosa, Claudia M.

AU - Welliver, Robert C.

AU - Wolkoff, Leslie I.

AU - Yogev, Ram

AU - Checchia, Paul A.

AU - Domachowske, Joseph B.

AU - Halasa, Natasha

AU - McBride, Scott J.

AU - Kumar, Veena R.

AU - McLaurin, Kimmie K.

AU - Rizzo, Christopher P.

AU - Ambrose, Christopher S.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. Results Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.

AB - Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting ≥24 hours among preterm infants 29 to 35 wGA and aged <12 months who did not receive RSV IP within 35 days before onset of symptoms were identified and characterized. Results Results were similar across the two seasons. Among infants with community-acquired RSVH (N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.

KW - hospitalizations

KW - immunoprophylaxis

KW - infants

KW - palivizumab

KW - respiratory syncytial virus

UR - http://www.scopus.com/inward/record.url?scp=85073800678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073800678&partnerID=8YFLogxK

U2 - 10.1055/s-0039-1681014

DO - 10.1055/s-0039-1681014

M3 - Article

C2 - 30991438

AN - SCOPUS:85073800678

SN - 0735-1631

VL - 37

SP - 421

EP - 429

JO - American journal of perinatology

JF - American journal of perinatology

IS - 4

ER -

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this