James L. Wynn, Jan A. Hazelzet, Thomas P. Shanley, Hector R. Wong, Derek S. Wheeler*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The management of the child with sepsis represents the sine qua non of pediatric critical care medicine. Overwhelming sepsis and septic shock often manifest with concurrent derangements of cardiovascular function, intravascular volume status, respiratory function, immune regulation, renal function, coagulation, hepatic function, and metabolic function - sepsis literally affects every organ system to some degree. The degree to which any of these derangements are manifest in a given child is highly variable and influenced by multiple host and pathogen factors, including the child's developmental stage, the presence or absence of co-morbidities, the host's immune/inflammatory state, the host's genetic background, and the specific pathogens involved. These factors combine, in turn, to profoundly influence the ultimate outcome. Successful management of critically ill children depends upon early recognition, early treatment with antibiotics, and early reversal of shock.

Original languageEnglish (US)
Title of host publicationGastroenterological, Endocrine, Renal, Hematologic, Oncologic and Immune Systems
PublisherSpringer-Verlag London Ltd
Number of pages27
ISBN (Electronic)9781447164166
ISBN (Print)1447164156, 9781447164159
StatePublished - Feb 1 2014


  • CARS
  • Early goal-directed therapy
  • MODS
  • SIRS
  • Sepsis
  • Septic shock
  • Severe sepsis
  • Shock

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Sepsis'. Together they form a unique fingerprint.

Cite this