Sepsis in pediatric cardiac intensive care

Derek S. Wheeler*, Hector R. Wong

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Objectives: In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function. Data Source: MEDLINE and PubMed. Conclusions: There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. However, at the same time, it is also evident that sepsis mortality has not improved enough, even with progress in our understanding of the molecular pathophysiology of sepsis.

Original languageEnglish (US)
Pages (from-to)S266-S271
JournalPediatric Critical Care Medicine
Volume17
Issue number8
DOIs
StatePublished - 2016

Keywords

  • biomarkers
  • outcomes
  • pathophysiology
  • pediatrics
  • severe sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

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