Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors

Jolanta M. Topczewska, Jacek Topczewski, Lilianna Solnica-Krezel, Brigid L M Hogan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Mouse Foxc1 (previously Mf1) is a member of the conserved forkhead/winged helix transcription factor gene family. It is expressed in many mesodermal tissues including paraxial mesoderm of the trunk and head, prechondrogenic mesenchyme, branchial arches and developing kidney. Homozygous mutants die perinatally with hydrocephalus and skeletal, cardiovascular, ocular and genitourinary defects. Here, we report the cloning and expression of two zebrafish foxc1 homologues, foxc1a and foxc1b. During gastrulation and somitogenesis both genes have similar expression patterns in the hypoblast, paraxial and presomitic mesoderm, somites and trunk adaxial cells. Expression in the somites is downregulated as they differentiate, but is maintained in the sclerotome. Later, some differences in expression pattern emerge. For example, only foxc1a transcripts are detected in the pronephros primodia and in the head mesoderm around the eyes, while only foxc1b is expressed in the pharyngeal arches and pectoral fins. Early expression of foxc1a in the paraxial mesoderm is modified in chordino, swirl, somitabun, and spadetail mutants.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalMechanisms of Development
Volume100
Issue number2
DOIs
StatePublished - Feb 12 2001

Keywords

  • Adaxial cells
  • Cephalic mesoderm
  • Forkhead
  • Foxc1
  • In situ hybridization
  • Mutants
  • Paraxial mesoderm
  • Segmentation
  • Somites
  • Zebrafish

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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