Sequence homologies in the 5' regions of four Drosophila heat-shock genes

R. Holmgren, V. Corces, R. Morimoto, R. Blackman, M. Meselson

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112 Scopus citations

Abstract

We report nucleotide sequences of the regions surrounding the 5' ends of the genes for Drosophila melanogaster heat-shock proteins hsp83, hsp68, and hsp26, located at chromosome position 63BC, 95D, and 67B, respectively. As in other eukaryotic genes, the sequence T-A-T-A-A-A-(TA) occurs about 30 nucleotides upstream from the sites of mRNA initiation. Three additional sequence homologies and a dyad symmetry were noted at approximately corresponding locations in the three genes and in the gene for another heat-shock protein, hsp70. We also found an intron near the 5' end of the hsp83 gene, with sequences at its boundaries typical of splice sites found in other organisms.

Original languageEnglish (US)
Pages (from-to)3775-3778
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number6 I
DOIs
StatePublished - 1981

ASJC Scopus subject areas

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