Sequential processing deficits in schizophrenia: Relationship to neuropsychology and genetics

S. Kristian Hill*, Olivia Bjorkquist, Tarra Carrathers, Jarett E. Roseberry, William C. Hochberger, Jeffrey R. Bishop

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Utilizing a combination of neuropsychological and cognitive neuroscience approaches may be essential for characterizing cognitive deficits in schizophrenia and eventually assessing cognitive outcomes. This study was designed to compare the stability of select exemplars for these approaches and their correlations in schizophrenia patients with stable treatment and clinical profiles. Reliability estimates for serial order processing were comparable to neuropsychological measures and indicate that experimental serial order processing measures may be less susceptible to practice effects than traditional neuropsychological measures. Correlations were moderate and consistent with a global cognitive factor. Exploratory analyses indicated a potentially critical role of the Met allele of the Catechol-O-methyltransferase (COMT) Val158Met polymorphism in externally paced sequential recall. Experimental measures of serial order processing may reflect frontostriatal dysfunction and be a useful supplement to large neuropsychological batteries.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalSchizophrenia Research
Volume151
Issue number1-3
DOIs
StatePublished - Dec 1 2013

Keywords

  • COMT
  • Neuropsychology
  • Reliability
  • Serial order processing
  • Working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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