Serial Observations of Angiotensin-Converting Enzyme and Pulmonary Function in Sarcoidosis

L. Jean Weaver, Norman H. Solliday*, Lillian Celic, David Cugell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Fifty-six measurements of angiotensin-converting enzyme (ACE) level, diffusing capacity (D, CO), and total lung capacity (TLC) were made in 18 sarcoid patients with a maximum of 25 months of follow-up observation. During spontaneous or corticosteroid-induced changes in disease activity, there was a significant inverse correlation between changes in ACE level and changes in DLCO and between changes in ACE level and changes in TLC. These observations suggest that ACE measurement may be a useful adjunct to pulmonary function tests to follow the course of sarcoidosis and to monitor the effects of corticosteroid therapy on the lung.

Original languageEnglish (US)
Pages (from-to)931-934
Number of pages4
JournalArchives of Internal Medicine
Volume141
Issue number7
DOIs
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Internal Medicine

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